Radiographic evaluation of the effect of diphenoxylate and loperamide on the transit time of the contrast media of gastro-intestinal tract in cat

Subject Areas : Veterinary Clinical Pathology

Abdolvahed  Moarabi ¹ (Associate Professor, Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.)
Alireza  Ghadiri ² (Professor, Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.)
Bahman  Mosallanejad ³ (Professor, Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.)
Mahsa  Ghodrati ⁴ (D.V.M. Graduate, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.)

Received: 2019-03-10 Accepted : 2021-03-01 Published : 2021-01-20

Keywords: Cat, Radiography, contrast media, Diphenoxylate, Loperamide,

Abstract :

Radiography with contrast media is a diagnostic imaging technique with high-resolution that plays a prominent role in showing the transit time of gastrointestinal system. The purpose of the present research was to evaluate the effects of diphenoxylate and loperamide on the transit time of contrast media from the gastrointestinal in cat. The study was performed on twenty healthy female cat. The cats were divided into four equal groups. The first group (control) was received ketamine with diazepam, 40 min before administration of the contrast media. The second group was received diphenoxylate 0.1 mg/kg, the third group loperamide 0.1 mg/kg, and the fourth group loperamide 0.2 mg/kg, 30 min before administration of contrast media. Tranquilizer drugs were administered to all groups. Then the radiography was performed at times zero, 20, 40 and 60 min, and every hour until reaching the contrast media to colon. All groups that were received drug had a significant difference at the beginning of emptying with control group (p < 0.05). The mean total transit time of the stomach was 52 min for the control group, the diphenoxylate 120, the loperamide 0.1 mg/kg 156 and for the loperamide 0.2 mg/kg 204 min respectively. There was a significant difference between the control and the drug-receiving groups as well as the two groups of diphenoxylate and loperamide 0.2 mg/kg at the time of complete stomach emptying (p < 0.05). In conclusion, it was showed that Loperamide with dosage 0.2 mg/kg had the most delay effect in emptying of the gastrointestinal tract in cat.

References:

• Baker, D.E. (2007). Loperamide: a pharmacological review. Reviews in Gastroenterological Disorders, 7(3): 11-18.


• Cho, Y.K., Kim, S.C. and Lee, K.C. (2012). Radiographic estimation of colonic transit time with Kolomark in normal dogs. Journal of Veterinary Clinics, 29(3): 237-241.


• Croffie, J.M., Ellett, M.L., Lou, Q. and Fitzgerald, J.F. (1999). A comparision of the effect of three sedatives on esophageal sphincters in cats. Digestive Diseaases, 17(2): 113-120.


• Faghihi, S.M. and Gandomi Sani, H.R. (2013). Veterinary Pharmacy. 3rd ed., Tehran University Press, pp: 484-485. [In Persian] 


• Ettinger, S.J. and Feldman, E.C. (2010). Textbook of Veterinary Internal Medicine: Diseases of the Dog and Cat. 7th ed., California: St. Louis, Missouri, pp: 1332-1407.


• Hare, C.; Halligan, S., Bartram, C.I., Platt, K. and Raleigh, G. (2000). Cisapride or metoclopramide to accelerate small bowel transit during barium follow-through examination? Abdominal Imaging, 25(3): 243-245.


• Hogan, P.M. and Aronson, E. (1988). Effect of sedation on transit time of feline gastrointestinal contrast studies. Veterinary Radiology & Ultrasound, 29(2): 85-88.


• Jansen, M., Fass, J., Tittel, A., Mumme, T., Anurov, M., Titkova, S., et al. (2002). Influence of postoperative epidural analgesia with bupivacaine on intestinal motility, transit time, and anastomotic healing. World Journal of Surgery, 26(3): 303-306.


• Katzung, B.G., Masters, S.B. and Trevor, A.J. (2015). Basic and clinical pharmacology. 13th ed., USA: McGraw-Hill Medical, pp: 531-550.


• Kealy, J.K. (2000). Diagnostic Radiology and Ultrasonography of the Dog and Cat. 6th ed., W.B. Saunders Publisher, pp: 25-35.


• Kealy, J.K., McAllister, H. and Graham, J.P. (2010). Diagnostic Radiology and Ultrasonography of the Dog and Cat. 5th ed. Elsevier Health Sciences, pp: 40-65.


• Kirby, M.G., Dukes, G.E., Heizer, W.D., Bryson, J.C. and Powell, J.R. (1989). Effect of metoclopramide, bethanechol, and loperamide on gastric residence time, gastric emptying, and mouth-to-cecum transit time. Pharmacotherapy, 9(4): 226-231.


• Lavin, L.M. (2003). Radiology in Veterinary Technology. 3th ed., W.B. Saunders Company, Philadelphia, pp: 244-248.


• Maddison, E., Stephen, W. and David, B. (2008). Small animal clinical pharmacology. 2nd ed., USA: Saunders Elsevier, pp: 345-360.


• Thrall, D.E. (2013). Textbook of Veterinary Diagnostic Radiology. Elsevier Health Sciences, pp: 769-810.


• Weber, M.P., Stambouli, F., Martin, L.J., Dumon, H.J., Biourge, V.C. and Nguyen, P.G. (2002). Influence of age and body size on gastrointestinal transit time of radiopaque markers in healthy dogs. American Journal of Veterinary Research, 63(5): 677-82.


• Yamada, K., Furuya, A., Akimoto, M., Maki, T., Suwa, T. and Ogata, H. (1995).  Evaluation of gastrointestinal transit controlled-beagle dog as a suitable animal model for bioavailability testing of sustained-release acetaminophen dosage form. International Journal of Pharmaceutics, 119(1): 1-10.


• Zhang, J.S., Ye, L.P., Zhang, J.L., Wang, C.Y. and Chen, J.Y. (2011). Intramuscular injection of metoclopramide decreases the gastric transit time and does not increase the complete examination rate of capsule endoscopy: a prospective randomized controlled trial. Hepato-gastroenterology, 58(110-111): 1618-1621.