Effect of Beta asarone on concentration of TNF-α in a rat model of Alzheimer’s disease
Subject Areas :
Veterinary Clinical Pathology
Golshid
Saki
1
(PhD. Graduate, Department of Biology, Faculty of Basic Science, Fars Science and Research branch, Islamic Azad University, Fars, Iran؛ PhD. Graduate, Department of Biology, Faculty of Science, Agriculture and New Technologies, Shiraz)
Akram
Eidi
2
(Professor, Department of Biology, Faculty of Basic Science, Science and Research Branch, Islamic Azad University, Tehran, Iran.)
Pejman
Mortazavi
3
(- Associate Professor, Department of Pathology, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.)
Akbar
Vahdati
4
(Professor, Department of Biology, Faculty of Basic Science, Fars Science and Research branch, Islamic Azad University, Fars, Iran؛ Professor, Department of Biology, Faculty of Science, Agriculture and New Technologies, Shiraz Branch,)
Negar
Panahi
5
(Assistant Professor, Department of Basic Sciences, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.)
Received: 2018-01-16
Accepted : 2018-10-24
Published : 2021-04-21
Keywords:
Alzheimer,
Rat,
β-asarone,
β-amyloid,
Tumor Necrosis Factor-alpha,
Abstract :
Beta asarone which is the major component of Acorus tatarinowii Schott, can pass through the blood-brain-barrier and affect the central nervous system. In the present study, effect of beta asarone on TNF-α level was investigated in β-amyloid-induced alzheimeric male rats. The adult male rats were randomly divided into 9 groups of 6: normal control, sham-operated control, β-asarone (12.5, 25 and 50 mg/kg PO, daily for 50 days), alzheimeric control (bilateral intrahippocampal injection of 4 µl of β-amyloid 1-42) and alzheimeric β-asarone receiving (12.5, 25 and 50 mg/kg PO β-asarone daily for 30 days following β-amyloid injection and subsequent doses of beta asarone for 3 weeks). The rats were sacrificed at the end of the experiment and the TNF-α level was measured in brain homogenate. Our results showed that administration of β-asarone (25 and 50 mg/kg) significantly decreased the TNF-α level (p<0.001) in alzheimeric rats. Thus, these results indicate that β-asarone is effective in providing protection against inflammation induced by β-amyloid.
References:
Alderton, W.K., Cooper, C.E. and Knowles, R.G. (2001). Nitric oxide synthases: structure, function and inhibition. Biochemical Journal, 357(3): 593-615.
Alvarez, A., Cacabelos, R., Sanpedro, C., Garcia-Fantini, M. and Aleix-andre, M. (2007). Serum TNF-alpha levels are increased and correlate negatively with free IGF-I in Alzheimer disease. Neurobiology of Aging, 28(4): 533-536.
Ansari, N. and Khodagholi, F. (2013). Natural products as promising drug candidates for the treatment of Alzheimer’s disease: molecular mechanism aspect. Current Neuropharmacology, 11(4): 414-429.
Bertram, L., Lill, C.M. and Tanzi, R.E. (2010). The genetics of Alzheimer disease: back to the future. Neuron, 68(2): 270-281.
Chang, W. and Teng, J. (2015). β-asarone prevents Aβ25-35-induced inflammatory responses and autophagy in SH-SY5Y cells: down expression Beclin-1, LC3B and up expression Bcl-2. International Journal of Clinical and Experimental Medicine, 8(11): 20658-20663.
Chen, X., Walker, D.G., Schmidt, A.M., Arancio, O., Lue, L.F. and Yan, S.D. (2007). RAGE: a potential target for Abeta-mediated cellular perturbation in Alzheimer’s disease. Current Molecular Medicine, 7(8): 735-742.
Chen, Y.Z., Wang, Q.W., Liang, Y. and Fang, Y.Q. (2007). Protective effects of beta-asarone on cultured rat cortical neurons damage induced by glutamate. Zhong Yao Cai, 30(4): 436-438.
Cho, J., Kim, Y.H., Kong, J.Y., Yang, C.H. and Park, C.G. (2002). Protection of cultured rat cortical neurons from excitotoxicity by asarone, a major essential oil component in the rhizomes of Acorus gramineus. Life Sciences, 71(5): 591-599.
Chun, H.S., Kim, J.M., Choi, E.H. and Chang, N. (2008). Neuroprotective effects of several Korean medicinal plants traditionally used for stroke remedy. Journal of Medical Food, 11(2): 246-251.
Dobarro, M., Orejana, L., Aguirre, N. and Ramírez, M.J. (2013). Propranolol reduces cognitive deficits, amyloid β levels, tau phosphorylation and insulin resistance in response to chronic corticosterone administration. International Journal of Neuropsychopharmacology, 16(6): 1351-1360.
Fan, R., Xu, F., Previti, M.L., Davis, J., Grande, A.M., Robinson, J.K., et al. (2007). Minocycline reduces microglial activation and improves behavioral deficits in a transgenic model of cerebral microvascular amyloid. Journal of Neuroscience, 27(12): 3057-3063.
Fang, F., Lue, L.F., Yan, S., Xu, H., Luddy, J.S., Chen, D., et al. (2010). RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer’s disease. The FASEB Journal, 24(4): 1043-1055.
Fang, Y.Q., Fang, R.M., Fang, G.L., Jiang, Y. and Fu, S.Y. (2008). Effects of beta-asarone on expression of c-fos in kindling epilepsy rat brain. Zhongguo Zhong Yao Za Zhi, 33(5): 534-536.
Fang, Y.Q., Li, L. and Wu, Q.D. (2003). Effects of beta-asarone on gene expression in mouse brain. Zhong Yao Cai, 26(9): 650-652.
Fang, Y.Q. and Wei, G. (2002). To analyze if the Rhizoma Acori Tatarimowii naph-tha can go through the BBB or not with GC-MS. Zhong Yao Xin Yao Yu: Ling Chuang Yao Li, 13(3): 181-182.
Fu, S.Y., Fang, R.M., Fang, G.L., Xie, Y.H. and Fang, Y.Q. (2008). Effects of beta-asarone on expression of FOS and GAD65 in cortex of epileptic rat induced by penicillin. Zhong Yao Cai, 31(1): 79-81.
Geng, Y., Li, C., Liu, J., Xing, G., Zhou, L., Dong, M., et al. (2010). Beta-asarone improves cognitive function by suppressing neuronal apoptosis in the beta-amyloid hippocampus injection rats. Biological and Pharmaceutical Bulletin, 33(5): 836-843.
Han, L., Yin, K., Zhang, S., Wu, Z., Wang, C., Zhang, Q., et al. (2013). Dalesconols B inhibits lipopolysaccharide induced inflammation and suppresses NF-kappaB and p38/JNK activation in microglial cells. Neurochemistry International, 62(7): 913-921.
Huang, L., Deng, M., He, Y. and Fang, Y. (2015). β-asarone and levodopa coadministration protects against 6-OHDA-induced damage in parkinsonian rat mesencephalon by regulting autophagy: down expression Beclin-1 and LC3B and up expression p62. Clinical and Experimental Pharmacology and Physiology, 42(3): 269-277.
Imbimbo, B.P., Lombard, J. and Pomara, N. (2005). Pathophysiology of Alzheimer's disease. Neuroimaging Clinics of North America, 15(4): 727-753.
Jayasooriya, R.G., Kang, C.H., Seo, M.J., Choi, Y.H., Jeong, Y.K. and Kim, G.Y. (2011). Exopolysaccharide of Laetiporus sulphureus var. miniatus down regulates LPS-induced production of NO, PGE(2), and TNF-alpha in BV2 microglia cells via suppression of the NF-kappaB pathway. Food and Chemical Toxicology, 49(11): 2758-2764.
Jean, Y.Y., Baleriola, J., Fà, M., Hengst, U. and Troy, C.M. (2015). Stereotaxic infusion of oligomeric Amyloid-beta into the mouse hippocampus. Journal of Visualized Experiments, 100(6): e52805.
Kang, C.H., Jayasooriya, R.G., Dilshara, M.G., Choi, Y.H., Jeong, Y.K., Kim, N.D., et al. (2012). Caffeine suppresses lipopolysaccharide-stimulated BV2 microglial cells by suppressing Akt-mediated NF-kappaB activation and ERK phosphorylation. Food and Chemical Toxicology, 50(12): 4270-4276.
Klein, R.L., Dayton, R.D., Diaczynsky, C.G. and Wang, D.B. (2010). Pronounced micro gliosis and neurodegeneration in aged rats after tau gene transfer. Neurobiology of Aging, 31(12): 2091-2102.
Lee, B., Sur, B., Cho, S.G., Yeom, M., Shim, I., Lee, H., et al. (2015). Effect of Beta-Asarone on impairment of spatial working memory and apoptosis in the hippocampus of rats exposed to chronic corticosterone administration. Biomolecules and Therapeutics (Seoul), 23(6): 571-581.
Lee, B., Sur, B., Shim, I., Lee, H. and Hahm, D.H. (2014). Baicalin improves chronic corticosterone-induced learning and memory deficits via the enhancement of impaired hippocampal brain-derived neurotrophic factor and cAMP response element-binding protein expression in the rat. Journal of Natural Medicines, 68(1): 132-143.
Li, C., Xing, G., Dong, M., Zhou, L., Li, J., Wang, G., et al. (2010). Beta-asarone protection against beta-amyloid-induced neurotoxicity in PC12 cells via JNK signaling and modulation of Bcl-2 family proteins. European Journal of Pharmacology, 635(1-3): 96-102.
Li, Z., Zhao, G., Qian, S., Yang, Z., Chen, X., Chen, J., et al. (2012). Cerebrovascular protection of beta-asarone in Alzheimer’s disease rats: a behavioral, cerebral blood flow, biochemical and genic study. Journal of Ethnopharmacology, 144(2): 305-312.
Lim, H.W., Kumar, H., Kim, B.W., More, S.V., Kim, I.W., Park, J.I., et al. (2014). β-Asarone (cis-2,4,5-trimethoxy-1-allyl phenyl), attenuates pro-inflammatory mediators by inhibiting NF-κB signaling and the JNK pathway in LPS activated BV-2 microglia cells. Food and Chemical Toxicology, 72(10): 265-272.
Liu, J., Li, C., Xing, G., Zhou, L., Dong, M., Geng, Y., et al. (2010). Beta-asarone attenuates neuronal apoptosis induced by Beta amyloid in rat hippocampus. Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan, 130(5): 737-746.
Lue, L.F., Walker, D.G., Brachova, L., Beach, T.G., Rogers, J., Schmidt, A.M., et al. (2001). Involvement of microglial receptor for advanced glycation end products (RAGE) in Alzheimer’s disease: identification of a cellular activation mechanism. Experimental Neurology, 171(1): 29-45.
Maltseva, A.V., Bystryakc, S. and Galzitskayad, O.V. (2011). The role of β-amyloid peptide in neurodegenerative diseases. Ageing Research Reviews, 10(4): 440-452.
Ojala, J., Alafuzoff, I., Herukka, S.K., Van Groen, T., Tanila, H. and Pirttilä, T. (2009). Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients. Neurobiology of Aging, 30(2): 198-209.
Olajide, O.A., Bhatia, H.S., De Oliveira, A.C., Wright, C.W. and Fiebich, B.L. (2013). Antineuroinflammatory properties of synthetic cryptolepine in human neuroblastoma cells: possible involvement of NF-kappaB and p38 MAPK inhibition. European Journal of Medicinal Chemistry, 63(5): 333-339.
Paxinos, G. and Watson, C. (1998). The Rat Brain in Stereotaxic Coordinates. 4th ed., San Diego: Academic Press, pp: 45-46.
Pettigrew, L.C., Kindy, M.S., Scheff, S., Springer, J.E., Kryscio, R.J., Li, Y., et al. (2008). Focal cerebral ischemia in the TNFalpha-transgenic rat. Journal of Neuroinflammation, 5: 47.
Qaseem, A., Snow, V., Cross, J.T.J.r., Forciea, M.A., Hopkins, R.J.r., Shekelle, P., et al. (2008). Current Pharmacologic Treatment of Dementia: A Clinical Practice Guideline from the American College of Physicians and the American Academy of Family Physicians. Annal of Internal Medicine, 148(5): 370–378.
Qiduan, W.U., Qinghe, W.U., Qiwen, W. and Yuzhi, C. (2008). Study on anti-thrombosis effect of volatile oil of Acorus Tatarinowii Schott and b-asarone. Traditional Chinese Drug Research and Clinical Pharmacology, 19(1): 29-31.
Roozendaal, B., Hahn, E.L., Nathan, S.V., De Quervain, D.J. and McGaugh, J.L. (2004). Glucocorticoid effects on memory retrieval require concurrent noradrenergic activity in the hippocampus and basolateral amygdala. Journal of Neuroscience, 24(37): 8161-8169.
Saura, C.A. and Valero, J. (2011). The role of CREB signaling in Alzheimer’s disease and other cognitive disorders. Nature Reviews Neuroscience, 22(2): 153-169.
Thies, W. and Bleiler, L. (2012). Alzheimer’s disease facts and figures. Alzheimer's and Dementia, 8(2): 131-168.
Vaynman, S., Ying, Z. and Gomez-Pinilla, F. (2008). Interplay between brain-derived neurotrophic factor and signal transduction modulators in the regulation of the effects of exercise on synaptic-plasticity. Neuroscience, 122(3): 647-657.
Wang, D.B., Dayton, R.D., Zweig, R.M. and Klein, R.L. (2010). Transcriptome analysis of a tau overexpression model in rats implicates an early pro-inflammatory response. Experimental Neurology, 224(1): 197-206.
Wei, G., Chen, Y.B., Chen, D.F., Lai, X.P., Liu, D.H., Deng, R.D., et al. (2013). Beta Asarone inhibits neuronal apoptosis via the CaMKII/CREB/Bcl-2 signaling pathway in an in vitro model and AbetaPP/PS1 mice. Journal of Alzheimer’s Disease, 33(3): 863-880.
Willians, C.M., El Mohsen, M.A., Vauzour, D., Rendeiro, C., Butler, L.T., Ellis, J.A., et al. (2008). Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels. Free Radical Biology and Medicine, 45(3): 295-305.
Yan, S.S., Chen, D., Yan, S., Guo, L., Du, H. and Chen, J.X. (2012). RAGE is a key cellular target for Abeta-induced perturbation in Alzheimer’s disease. Frontiers in Bioscience, 4(1): 240-250.
Yang, C., Li, X., Mo, Y., Liu, S., Zhao, L., Ma, X., et al. (2016). β-Asarone mitigates amyloidosis and down regulates RAGE in a transgenic mouse model of Alzheimer’s disease. Cellular and Molecular Neurobiology, 36(1): 121-130.
Yang, Y., Xuan, L., Chen, H., Dai, S., Ji, L., Bao, Y., et al. (2017). Neuroprotective effects and mechanism of β-Asarone against Aβ1–42-induced injury in astrocytes. Evidence-Based Complementary and Alternative Medicine, 17(1): 1-14.
Yang, Y.X., Chen, Y.T., Zhou, X.J., Hong, C.L., Li, C.Y. and Guo, J.Y. (2013). Beta-asarone, a major component of Acorus tatarinowii Schott, attenuates focal cerebral ischemia induced by middle cerebral artery occlusion in rats. BMC Complementary and Alternative Medicine, 13(1): 236.
Yi-zhi, C., Ruo-ming, F., Gang, W., Shuang-feng, L., Yu-feng, H.E., Shu-ying, W., et al. (2004). Effect of volatile oil of Acorus and b-Asarone on Vasomotion and anti-platelet Aggregation in Rats with Hyperlipidemia. Chinese Journal of Integrated Traditional and Western Medicine, 24(1): 16-18.
Zhaorigetu, S., Yang, Z., Toma, I., McCaffrey, T.A. and Hu, C.A. (2011). Apolipoprotein L6, induced in atherosclerotic lesions, promotes apoptosis and blocks Beclin 1-dependent autophagy in atherosclerotic cells. The Journal of Biological Chemistry, 286(31): 27389-27398.
Zou, D.J., Wang, G., Liu, J.C., Dong, M.X., Li, X.M., Zhang, C., et al. (2011). Beta-asarone attenuates beta-amyloid-induced apoptosis through the inhibition of the activation of apoptosis signal-regulating kinase 1 in SH-SY5Y cells. Die Pharmazie, 66(1): 44-51.
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Alderton, W.K., Cooper, C.E. and Knowles, R.G. (2001). Nitric oxide synthases: structure, function and inhibition. Biochemical Journal, 357(3): 593-615.
Alvarez, A., Cacabelos, R., Sanpedro, C., Garcia-Fantini, M. and Aleix-andre, M. (2007). Serum TNF-alpha levels are increased and correlate negatively with free IGF-I in Alzheimer disease. Neurobiology of Aging, 28(4): 533-536.
Ansari, N. and Khodagholi, F. (2013). Natural products as promising drug candidates for the treatment of Alzheimer’s disease: molecular mechanism aspect. Current Neuropharmacology, 11(4): 414-429.
Bertram, L., Lill, C.M. and Tanzi, R.E. (2010). The genetics of Alzheimer disease: back to the future. Neuron, 68(2): 270-281.
Chang, W. and Teng, J. (2015). β-asarone prevents Aβ25-35-induced inflammatory responses and autophagy in SH-SY5Y cells: down expression Beclin-1, LC3B and up expression Bcl-2. International Journal of Clinical and Experimental Medicine, 8(11): 20658-20663.
Chen, X., Walker, D.G., Schmidt, A.M., Arancio, O., Lue, L.F. and Yan, S.D. (2007). RAGE: a potential target for Abeta-mediated cellular perturbation in Alzheimer’s disease. Current Molecular Medicine, 7(8): 735-742.
Chen, Y.Z., Wang, Q.W., Liang, Y. and Fang, Y.Q. (2007). Protective effects of beta-asarone on cultured rat cortical neurons damage induced by glutamate. Zhong Yao Cai, 30(4): 436-438.
Cho, J., Kim, Y.H., Kong, J.Y., Yang, C.H. and Park, C.G. (2002). Protection of cultured rat cortical neurons from excitotoxicity by asarone, a major essential oil component in the rhizomes of Acorus gramineus. Life Sciences, 71(5): 591-599.
Chun, H.S., Kim, J.M., Choi, E.H. and Chang, N. (2008). Neuroprotective effects of several Korean medicinal plants traditionally used for stroke remedy. Journal of Medical Food, 11(2): 246-251.
Dobarro, M., Orejana, L., Aguirre, N. and Ramírez, M.J. (2013). Propranolol reduces cognitive deficits, amyloid β levels, tau phosphorylation and insulin resistance in response to chronic corticosterone administration. International Journal of Neuropsychopharmacology, 16(6): 1351-1360.
Fan, R., Xu, F., Previti, M.L., Davis, J., Grande, A.M., Robinson, J.K., et al. (2007). Minocycline reduces microglial activation and improves behavioral deficits in a transgenic model of cerebral microvascular amyloid. Journal of Neuroscience, 27(12): 3057-3063.
Fang, F., Lue, L.F., Yan, S., Xu, H., Luddy, J.S., Chen, D., et al. (2010). RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer’s disease. The FASEB Journal, 24(4): 1043-1055.
Fang, Y.Q., Fang, R.M., Fang, G.L., Jiang, Y. and Fu, S.Y. (2008). Effects of beta-asarone on expression of c-fos in kindling epilepsy rat brain. Zhongguo Zhong Yao Za Zhi, 33(5): 534-536.
Fang, Y.Q., Li, L. and Wu, Q.D. (2003). Effects of beta-asarone on gene expression in mouse brain. Zhong Yao Cai, 26(9): 650-652.
Fang, Y.Q. and Wei, G. (2002). To analyze if the Rhizoma Acori Tatarimowii naph-tha can go through the BBB or not with GC-MS. Zhong Yao Xin Yao Yu: Ling Chuang Yao Li, 13(3): 181-182.
Fu, S.Y., Fang, R.M., Fang, G.L., Xie, Y.H. and Fang, Y.Q. (2008). Effects of beta-asarone on expression of FOS and GAD65 in cortex of epileptic rat induced by penicillin. Zhong Yao Cai, 31(1): 79-81.
Geng, Y., Li, C., Liu, J., Xing, G., Zhou, L., Dong, M., et al. (2010). Beta-asarone improves cognitive function by suppressing neuronal apoptosis in the beta-amyloid hippocampus injection rats. Biological and Pharmaceutical Bulletin, 33(5): 836-843.
Han, L., Yin, K., Zhang, S., Wu, Z., Wang, C., Zhang, Q., et al. (2013). Dalesconols B inhibits lipopolysaccharide induced inflammation and suppresses NF-kappaB and p38/JNK activation in microglial cells. Neurochemistry International, 62(7): 913-921.
Huang, L., Deng, M., He, Y. and Fang, Y. (2015). β-asarone and levodopa coadministration protects against 6-OHDA-induced damage in parkinsonian rat mesencephalon by regulting autophagy: down expression Beclin-1 and LC3B and up expression p62. Clinical and Experimental Pharmacology and Physiology, 42(3): 269-277.
Imbimbo, B.P., Lombard, J. and Pomara, N. (2005). Pathophysiology of Alzheimer's disease. Neuroimaging Clinics of North America, 15(4): 727-753.
Jayasooriya, R.G., Kang, C.H., Seo, M.J., Choi, Y.H., Jeong, Y.K. and Kim, G.Y. (2011). Exopolysaccharide of Laetiporus sulphureus var. miniatus down regulates LPS-induced production of NO, PGE(2), and TNF-alpha in BV2 microglia cells via suppression of the NF-kappaB pathway. Food and Chemical Toxicology, 49(11): 2758-2764.
Jean, Y.Y., Baleriola, J., Fà, M., Hengst, U. and Troy, C.M. (2015). Stereotaxic infusion of oligomeric Amyloid-beta into the mouse hippocampus. Journal of Visualized Experiments, 100(6): e52805.
Kang, C.H., Jayasooriya, R.G., Dilshara, M.G., Choi, Y.H., Jeong, Y.K., Kim, N.D., et al. (2012). Caffeine suppresses lipopolysaccharide-stimulated BV2 microglial cells by suppressing Akt-mediated NF-kappaB activation and ERK phosphorylation. Food and Chemical Toxicology, 50(12): 4270-4276.
Klein, R.L., Dayton, R.D., Diaczynsky, C.G. and Wang, D.B. (2010). Pronounced micro gliosis and neurodegeneration in aged rats after tau gene transfer. Neurobiology of Aging, 31(12): 2091-2102.
Lee, B., Sur, B., Cho, S.G., Yeom, M., Shim, I., Lee, H., et al. (2015). Effect of Beta-Asarone on impairment of spatial working memory and apoptosis in the hippocampus of rats exposed to chronic corticosterone administration. Biomolecules and Therapeutics (Seoul), 23(6): 571-581.
Lee, B., Sur, B., Shim, I., Lee, H. and Hahm, D.H. (2014). Baicalin improves chronic corticosterone-induced learning and memory deficits via the enhancement of impaired hippocampal brain-derived neurotrophic factor and cAMP response element-binding protein expression in the rat. Journal of Natural Medicines, 68(1): 132-143.
Li, C., Xing, G., Dong, M., Zhou, L., Li, J., Wang, G., et al. (2010). Beta-asarone protection against beta-amyloid-induced neurotoxicity in PC12 cells via JNK signaling and modulation of Bcl-2 family proteins. European Journal of Pharmacology, 635(1-3): 96-102.
Li, Z., Zhao, G., Qian, S., Yang, Z., Chen, X., Chen, J., et al. (2012). Cerebrovascular protection of beta-asarone in Alzheimer’s disease rats: a behavioral, cerebral blood flow, biochemical and genic study. Journal of Ethnopharmacology, 144(2): 305-312.
Lim, H.W., Kumar, H., Kim, B.W., More, S.V., Kim, I.W., Park, J.I., et al. (2014). β-Asarone (cis-2,4,5-trimethoxy-1-allyl phenyl), attenuates pro-inflammatory mediators by inhibiting NF-κB signaling and the JNK pathway in LPS activated BV-2 microglia cells. Food and Chemical Toxicology, 72(10): 265-272.
Liu, J., Li, C., Xing, G., Zhou, L., Dong, M., Geng, Y., et al. (2010). Beta-asarone attenuates neuronal apoptosis induced by Beta amyloid in rat hippocampus. Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan, 130(5): 737-746.
Lue, L.F., Walker, D.G., Brachova, L., Beach, T.G., Rogers, J., Schmidt, A.M., et al. (2001). Involvement of microglial receptor for advanced glycation end products (RAGE) in Alzheimer’s disease: identification of a cellular activation mechanism. Experimental Neurology, 171(1): 29-45.
Maltseva, A.V., Bystryakc, S. and Galzitskayad, O.V. (2011). The role of β-amyloid peptide in neurodegenerative diseases. Ageing Research Reviews, 10(4): 440-452.
Ojala, J., Alafuzoff, I., Herukka, S.K., Van Groen, T., Tanila, H. and Pirttilä, T. (2009). Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients. Neurobiology of Aging, 30(2): 198-209.
Olajide, O.A., Bhatia, H.S., De Oliveira, A.C., Wright, C.W. and Fiebich, B.L. (2013). Antineuroinflammatory properties of synthetic cryptolepine in human neuroblastoma cells: possible involvement of NF-kappaB and p38 MAPK inhibition. European Journal of Medicinal Chemistry, 63(5): 333-339.
Paxinos, G. and Watson, C. (1998). The Rat Brain in Stereotaxic Coordinates. 4th ed., San Diego: Academic Press, pp: 45-46.
Pettigrew, L.C., Kindy, M.S., Scheff, S., Springer, J.E., Kryscio, R.J., Li, Y., et al. (2008). Focal cerebral ischemia in the TNFalpha-transgenic rat. Journal of Neuroinflammation, 5: 47.
Qaseem, A., Snow, V., Cross, J.T.J.r., Forciea, M.A., Hopkins, R.J.r., Shekelle, P., et al. (2008). Current Pharmacologic Treatment of Dementia: A Clinical Practice Guideline from the American College of Physicians and the American Academy of Family Physicians. Annal of Internal Medicine, 148(5): 370–378.
Qiduan, W.U., Qinghe, W.U., Qiwen, W. and Yuzhi, C. (2008). Study on anti-thrombosis effect of volatile oil of Acorus Tatarinowii Schott and b-asarone. Traditional Chinese Drug Research and Clinical Pharmacology, 19(1): 29-31.
Roozendaal, B., Hahn, E.L., Nathan, S.V., De Quervain, D.J. and McGaugh, J.L. (2004). Glucocorticoid effects on memory retrieval require concurrent noradrenergic activity in the hippocampus and basolateral amygdala. Journal of Neuroscience, 24(37): 8161-8169.
Saura, C.A. and Valero, J. (2011). The role of CREB signaling in Alzheimer’s disease and other cognitive disorders. Nature Reviews Neuroscience, 22(2): 153-169.
Thies, W. and Bleiler, L. (2012). Alzheimer’s disease facts and figures. Alzheimer's and Dementia, 8(2): 131-168.
Vaynman, S., Ying, Z. and Gomez-Pinilla, F. (2008). Interplay between brain-derived neurotrophic factor and signal transduction modulators in the regulation of the effects of exercise on synaptic-plasticity. Neuroscience, 122(3): 647-657.
Wang, D.B., Dayton, R.D., Zweig, R.M. and Klein, R.L. (2010). Transcriptome analysis of a tau overexpression model in rats implicates an early pro-inflammatory response. Experimental Neurology, 224(1): 197-206.
Wei, G., Chen, Y.B., Chen, D.F., Lai, X.P., Liu, D.H., Deng, R.D., et al. (2013). Beta Asarone inhibits neuronal apoptosis via the CaMKII/CREB/Bcl-2 signaling pathway in an in vitro model and AbetaPP/PS1 mice. Journal of Alzheimer’s Disease, 33(3): 863-880.
Willians, C.M., El Mohsen, M.A., Vauzour, D., Rendeiro, C., Butler, L.T., Ellis, J.A., et al. (2008). Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels. Free Radical Biology and Medicine, 45(3): 295-305.
Yan, S.S., Chen, D., Yan, S., Guo, L., Du, H. and Chen, J.X. (2012). RAGE is a key cellular target for Abeta-induced perturbation in Alzheimer’s disease. Frontiers in Bioscience, 4(1): 240-250.
Yang, C., Li, X., Mo, Y., Liu, S., Zhao, L., Ma, X., et al. (2016). β-Asarone mitigates amyloidosis and down regulates RAGE in a transgenic mouse model of Alzheimer’s disease. Cellular and Molecular Neurobiology, 36(1): 121-130.
Yang, Y., Xuan, L., Chen, H., Dai, S., Ji, L., Bao, Y., et al. (2017). Neuroprotective effects and mechanism of β-Asarone against Aβ1–42-induced injury in astrocytes. Evidence-Based Complementary and Alternative Medicine, 17(1): 1-14.
Yang, Y.X., Chen, Y.T., Zhou, X.J., Hong, C.L., Li, C.Y. and Guo, J.Y. (2013). Beta-asarone, a major component of Acorus tatarinowii Schott, attenuates focal cerebral ischemia induced by middle cerebral artery occlusion in rats. BMC Complementary and Alternative Medicine, 13(1): 236.
Yi-zhi, C., Ruo-ming, F., Gang, W., Shuang-feng, L., Yu-feng, H.E., Shu-ying, W., et al. (2004). Effect of volatile oil of Acorus and b-Asarone on Vasomotion and anti-platelet Aggregation in Rats with Hyperlipidemia. Chinese Journal of Integrated Traditional and Western Medicine, 24(1): 16-18.
Zhaorigetu, S., Yang, Z., Toma, I., McCaffrey, T.A. and Hu, C.A. (2011). Apolipoprotein L6, induced in atherosclerotic lesions, promotes apoptosis and blocks Beclin 1-dependent autophagy in atherosclerotic cells. The Journal of Biological Chemistry, 286(31): 27389-27398.
Zou, D.J., Wang, G., Liu, J.C., Dong, M.X., Li, X.M., Zhang, C., et al. (2011). Beta-asarone attenuates beta-amyloid-induced apoptosis through the inhibition of the activation of apoptosis signal-regulating kinase 1 in SH-SY5Y cells. Die Pharmazie, 66(1): 44-51.
