Metastatic adenocarcinoma in a layer chicken flock (case report)
Subject Areas :
Veterinary Clinical Pathology
saeed seifi
1
(Associate Professor, Department of Animal Sciences, Faculty of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran.)
ali afzali larijani
2
(PhD Candidate in Veterinary Pathology, Faculty of Veterinary Medicine, Ferdowsi University, Mashhad, Iran.)
Received: 2019-06-23
Accepted : 2020-02-09
Published : 2020-08-22
Keywords:
Ovary,
layer chicken,
Intestine,
adenocarcinoma,
Metastasis,
Abstract :
In hens, spontaneous tumors of the ovary and, less frequently, of the oviduct, are common. Leiomyoma and oviduct adenocarcinoma are the most common tumors of the reproductive tract in laying hens. The present article, reports a metastatic adenocarcinoma in an 80 week old commercial layer chicken flock in second-cycle of egg production in Mazandaran province. Eight dead layer hens were referred to division of avian diseases of Amol University. On necropsy examination, the mesentery and serosal surface of the intestine was studded with grayish white nodules. The ovary contained varying sizes of multiple single to lobulated grayish white nodules. Also, ascites were seen in some cases. Tissue samples were taken and placed in 10% neutral buffered formalin. Microscopically, cuboidal neoplastic cells were arranged in acinar and tubular pattern in the serosal layer of intestine. The cells appeared as variable sized cuboidal cells with indistinct cell borders, eosinophilic granular cytoplasm, round nuclei, indistinct nucleoli and fine chromatin granules. The intestinal nodules showed neoplastic cells and structures similar to those of the ovary tumor.
References:
Alfonso, M., Adochiles, L., Hendrickson, V.M., Carver, D.K., Rodriguez, G.C. and Barnes, H.J. (2005). Metastatic adenocarcinoma in the lungs of older laying hens. Avian Diseases, 49(3): 430-432.
Anjum, A.D., Payne, L.N. and Appleby, E.C. (1989). Oestrogen and progesterone receptors and their relationship to histological grades of epithelial tumours of the magnum region of the oviduct of the domestic fowl. Journal of Comparative Pathology, 100(3): 275-286.
Ansenberger, K., Richards, C., Zhuge, Y., Barua, A., Bahr, J.M., Luborsky, J.L., et al. (2010). Decreased severity of ovarian cancer and increased survival in hens fed a flaxseed-enriched diet for 1 year. Gynecologic Oncology, 117(2): 341-347.
Barnes, M.N., Berry, W.D., Straughn, J.M., Kirby, T.O., Leath, C.A., Huh, W.K., et al. (2002). A pilot study of ovarian cancer chemoprevention using medroxyprogesterone acetate in an avian model of spontaneous ovarian carcinogenesis. Gynecologic Oncology, 87(1): 57-63.
Bwalaa, D.G., Duncan, N.M. and Bisschop, S.P.R. (2011). Uterine adenocarcinoma with transcoelomic metastases in breeder hens (Gallus domesticus). Journal of the South African Veterinary Association, 82(1): 53-55.
Carver D.K., Barnes H.J., Anderson K.E., Petitte J.N., Whitaker R., Berchuck A. and Rodriguez G.C. (2011). Reduction of ovarian and oviductal cancers in calorie-restricted laying chickens. Cancer prevention research, 4(4): 562-567.
Fredrikson, T.N. (1987). Ovarian tumors of the hen. Environmental Health Perspectives, 73(1): 35-51.
Hakim, A.A., Barry, C.P., Barnes, H.J., Anderson, K.E., Petitte, J., Whitaker, R., et al. (2009). Ovarian adenocarcinomas in the laying hen and women share similar alterations in p53, ras, and HER-2/neu. Cancer Prevention Research, 2(2): 114-121.
Kumar, R., Nair, M.G., Lakkawar, A.W. and Varshney, K.C. (2004). Ovarian adenocarcinoma in a guinea fowl (Numida meleagris) - a case report. Veterinarski Arhiv, 74(3): 245-249.
Mahjoor, A.A. and Nili, H. (2006). Studies on incidence and pathology of neoplasms of reproductive system of cull laying. Archives of Razi Institute, 61(3): 149-157.
Moore, C.B. and Siopes, T.D. (2004). Spontaneous ovarian adenocarcinoma in the domestic turkey breeder hen (Meleagris gallopavo): Effects of photoperiod and melatonin. Neuroendocrinology Letters, 25(1-2): 94-101.
Murdoch, W.J., Van Kirk, E.A. and Alexander, B.M. (2005). DNA damages in ovarian surface epithelial cells of ovulatory hens. Experimental Biology and Medicine (Maywood), 230(6): 429-433.
Reece, R.L. (1996). Some observations on naturally occurring neoplasms of domestic fowls in the state of Victoria, Australia (1977-87). Avian Pathology, 25(3): 407-447.
Reece, R.L. (2003). Other tumors of unknown etiology. In: Diseases of Poultry. Saif, Y.M., Swayne, D.E. and Fadly, A.M. editors. 11th ed., Iowa State University Press, Ames, IA, pp: 547-548.
Ritchie, B.W., Harrison, G.J. and Harrison, L.R. (1994). Avian Medicine, principles and application, Wingers Publishing Inc., pp: 758-774.
Srinivasan, P., Balachandran, C., Pazhanivel, N., Gopalakrishna Murthy, T.R., Saravanan, S., Gowthaman, V., et al. (2014). Spontaneous occurrence of oviduct infundibular adenocarcinoma in a layer chicken. Indian Journal of Veterinary Pathology, 38(4): 286-288.
Urick, M.E., Giles, J.R. and Johnson, P.A. (2009). Dietary aspirin decreases the stage of ovarian cancer in the hen. Gynecologic Oncology, 112(1): 166-170.
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Alfonso, M., Adochiles, L., Hendrickson, V.M., Carver, D.K., Rodriguez, G.C. and Barnes, H.J. (2005). Metastatic adenocarcinoma in the lungs of older laying hens. Avian Diseases, 49(3): 430-432.
Anjum, A.D., Payne, L.N. and Appleby, E.C. (1989). Oestrogen and progesterone receptors and their relationship to histological grades of epithelial tumours of the magnum region of the oviduct of the domestic fowl. Journal of Comparative Pathology, 100(3): 275-286.
Ansenberger, K., Richards, C., Zhuge, Y., Barua, A., Bahr, J.M., Luborsky, J.L., et al. (2010). Decreased severity of ovarian cancer and increased survival in hens fed a flaxseed-enriched diet for 1 year. Gynecologic Oncology, 117(2): 341-347.
Barnes, M.N., Berry, W.D., Straughn, J.M., Kirby, T.O., Leath, C.A., Huh, W.K., et al. (2002). A pilot study of ovarian cancer chemoprevention using medroxyprogesterone acetate in an avian model of spontaneous ovarian carcinogenesis. Gynecologic Oncology, 87(1): 57-63.
Bwalaa, D.G., Duncan, N.M. and Bisschop, S.P.R. (2011). Uterine adenocarcinoma with transcoelomic metastases in breeder hens (Gallus domesticus). Journal of the South African Veterinary Association, 82(1): 53-55.
Carver D.K., Barnes H.J., Anderson K.E., Petitte J.N., Whitaker R., Berchuck A. and Rodriguez G.C. (2011). Reduction of ovarian and oviductal cancers in calorie-restricted laying chickens. Cancer prevention research, 4(4): 562-567.
Fredrikson, T.N. (1987). Ovarian tumors of the hen. Environmental Health Perspectives, 73(1): 35-51.
Hakim, A.A., Barry, C.P., Barnes, H.J., Anderson, K.E., Petitte, J., Whitaker, R., et al. (2009). Ovarian adenocarcinomas in the laying hen and women share similar alterations in p53, ras, and HER-2/neu. Cancer Prevention Research, 2(2): 114-121.
Kumar, R., Nair, M.G., Lakkawar, A.W. and Varshney, K.C. (2004). Ovarian adenocarcinoma in a guinea fowl (Numida meleagris) - a case report. Veterinarski Arhiv, 74(3): 245-249.
Mahjoor, A.A. and Nili, H. (2006). Studies on incidence and pathology of neoplasms of reproductive system of cull laying. Archives of Razi Institute, 61(3): 149-157.
Moore, C.B. and Siopes, T.D. (2004). Spontaneous ovarian adenocarcinoma in the domestic turkey breeder hen (Meleagris gallopavo): Effects of photoperiod and melatonin. Neuroendocrinology Letters, 25(1-2): 94-101.
Murdoch, W.J., Van Kirk, E.A. and Alexander, B.M. (2005). DNA damages in ovarian surface epithelial cells of ovulatory hens. Experimental Biology and Medicine (Maywood), 230(6): 429-433.
Reece, R.L. (1996). Some observations on naturally occurring neoplasms of domestic fowls in the state of Victoria, Australia (1977-87). Avian Pathology, 25(3): 407-447.
Reece, R.L. (2003). Other tumors of unknown etiology. In: Diseases of Poultry. Saif, Y.M., Swayne, D.E. and Fadly, A.M. editors. 11th ed., Iowa State University Press, Ames, IA, pp: 547-548.
Ritchie, B.W., Harrison, G.J. and Harrison, L.R. (1994). Avian Medicine, principles and application, Wingers Publishing Inc., pp: 758-774.
Srinivasan, P., Balachandran, C., Pazhanivel, N., Gopalakrishna Murthy, T.R., Saravanan, S., Gowthaman, V., et al. (2014). Spontaneous occurrence of oviduct infundibular adenocarcinoma in a layer chicken. Indian Journal of Veterinary Pathology, 38(4): 286-288.
Urick, M.E., Giles, J.R. and Johnson, P.A. (2009). Dietary aspirin decreases the stage of ovarian cancer in the hen. Gynecologic Oncology, 112(1): 166-170.
