Effect of stanozolol and nandrolone decanoate hormones on serum concentration of erythropoeitin and testosterone in the cat

Subject Areas : Veterinary Clinical Pathology

Bahman Mosallanejad ¹ , Saad Gooraninejad ² , Seyed Reza Fatemi Tabatbaei ³ , Habib Amanipour ⁴

1 - Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
2 - Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
3 - Department of Basic Science, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
4 - Graduated from Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran

Received: 2017-03-07 Accepted : 2018-10-06 Published : 2018-10-23

Keywords: Testosterone, Cat, Stanozolol, Nandrolone decanoate, Erythropoietin,

Abstract :

Anabolic-androgenic steroids are used to stimulate appetite, muscle growth, and increase the production of red blood cells. The aim of the present study was to comparethe effect of stanozolol and nandrolone decanoate hormones on serum concentration of erythropoeitin and testosterone, their probable side effects on liver and body weight changes in the cat. For this purpose, ten healthy male cats were divided into two equal groups. Group A included  five cats which received stanozolol (25 mg/cat IM) once weekly for six weeks. Group B included five cats which received nandrolone decanoate (1 mg/kg IM) once weekly for six weeks. Blood samples were collected five times on days zero, 3, 14, 28 and 42, for measurement of testosterone and erythropoietin. Both stanozolol and nandrolone decanoate showed effective function in increasing serum concentration of erythropoeitin and testosterone, but the effect of stanozolol was more than nandrolone decanoate in increasing hormone levels. A significant difference (p>0.001) was observed between groups A and B at days 14, 28 and 42 in increasing erythropoeitin and at days 3, 14, 28 and 42 in increasing testosterone. None of the drugs had hepatotoxic effects and stanozolol was more effective than nandrolone decanoate in increasing body weight (p<0.001). The results showed that although both hormones had effective function in increasing erythropoietin, testosterone, and body weight in cats, but stanozolol was more effective than nandrolone decanoate. 

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