The Effect of Aerobic Step Training on Plasma Brain-Derived Neurotrophic Factor (BDNF) and Phosphorylated Tau Protein of Elderly Women
Subject Areas : New studies in exercise metabolism and physical activity
fatemeh dehghan haghighi lotfabadi
1
,
Ali Yaghoubi
2
1 - Department of physical education and sport science, Bojnourd branch, Islamic Azad University, Bojnourd, Iran
2 - Department of Sport Science, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran
Keywords: elderly women, Aerobics Training, Brain-Derived Neurotrophic Factor (BDNF), Phosphorylated Tau Protein,
Abstract :
the present study aimed to investigate the effect of 8 and 12 weeks of aerobic training on plasma BDNF levels of tau phosphorylated protein in elderly women with reduced cognitive function. For this propose 24 old women, 60 to 70 years old randomly selected and divided into experimental (n=12) or control (n=12) groups. The experimental group performed step aerobics training with an intensity of 60 to 70% of heart rate reserve, 3 sessions per week for 12 weeks. Plasma BDNF and tau phosphorylated protein level was measured with an ELISA kit. There was no significant difference between the levels of tau phosphorylated protein in the experimental and control group in different stages (p <0.05); Also, the results of repeated measures analysis of variance showed that despite the decrease in the level of tau phosphorylated protein, but there was no significant difference between the levels of this index in different stages of the study (p = 0.182). The plasma BDNF level of elderly women in the post-test stage (12 weeks) in the experimental group was significantly higher than the control group (p = 0.018). Also, plasma BDNF levels after 8 and 12 weeks in the experimental group were significantly higher than the pretest (P values were 0.021 and 0.004, respectively).These results suggest that the possible positive effects of exercise in the elderly with reduced cognitive function are not due to a decrease in the phosphorylated Tau protein and that neurogenic pathways are activated in this way.
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