Correlation of polymorphisms related to endometriosis: a meta-analysis

Subject Areas : genetics

Elnaz Zafari ¹ , Zahra Noormohammadi ² , Ashraf Moieni ³ , Morteza Karimipoor ⁴

1 - Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
2 - Science and Research Branch, Islamic Azad university, Poonak, Tehran
3 - Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
4 - Department of Molecular Medicine, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran

Received: 2024-01-29 Accepted : 2024-07-05 Published : 2025-01-08

Keywords: Endometriosis, Meta analysis, GREB1, miR148a,

Abstract :

Endometriosis is a hormone-related gynecological disorder characterized by severe pelvic pain and decreased fertility. However, most of its molecular mechanisms has been remained largely unknown. In the present study, a meta-analysis of 11 genome-associated datasets of patient-control pairs was performed. The meta-analysis analyses showed that loci including rs11674184 which located proximate to the GREB1 gene - a regulator of estrogen - and rs12700667 located upstream of miR148a gene, were significantly (P<0.05) associated with the risk of endometriosis. These findings may candidate specific genes which are crucial in estrogen signaling pathways. It may present unique opportunities for more targeted research efforts.