Correlation of polymorphisms related to endometriosis: a meta-analysis
Elnaz Zafari
1
(
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
)
Zahra Noormohammadi
2
(
Science and Research Branch, Islamic Azad university, Poonak, Tehran
)
Ashraf Moieni
3
(
Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
)
Morteza Karimipoor
4
(
Department of Molecular Medicine, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
)
Keywords: Endometriosis, Meta analysis, GREB1, miR148a,
Abstract :
Endometriosis is a hormone-related gynecological disorder characterized by severe pelvic pain and decreased fertility. However, most of its molecular mechanisms has been remained largely unknown. In the present study, a meta-analysis of 11 genome-associated datasets of patient-control pairs was performed. The meta-analysis analyses showed that loci including rs11674184 which located proximate to the GREB1 gene - a regulator of estrogen - and rs12700667 located upstream of miR148a gene, were significantly (P<0.05) associated with the risk of endometriosis. These findings may candidate specific genes which are crucial in estrogen signaling pathways. It may present unique opportunities for more targeted research efforts.
