A novel method for magnetic stem cell delivery to the spinal cord injury using magnet combination

Subject Areas : Journal of New Applied and Computational Findings in Mechanical Systems

majid poladian ¹ , fatemeh mokhtari ² , amir shamloo ³

1 - Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran;
2 - Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
3 - Department of Mechanical Engineering, Sharif University of Technology, Tehran, Iran

Received: 2023-08-27 Accepted : 2023-11-07 Published : 2023-11-22

Keywords: Magnet, Spinal Cord, Stem cell, Magnetic nanoparticles, delivery,

Abstract :

Magnetic stem cell delivery is a promising method for imaging and regenerating damaged cells. To increase the accuracy of delivering stem cells to the target tissue, a precise and cost-effective magnetic system is needed. In this research, a method for arranging magnets to improve the efficiency of stem cell transfer has been designed. The effects of these magnets on the movement of stem cells have been investigated. Different magnets with different arrangements were used for stem cell transfer and compared with each other. This research focuses on three categories of nerve-producing stem cells: bone marrow mesenchymal stem cells, nerve stem cells, and induced pluripotent stem cells. The results show that the arrangement of four magnets, with the side magnets of opposite poles, is more accurate in bringing all three types of stem cells to the injury site. The designed magnetic system can improve the accuracy of delivery of various stem cells in the spinal cord compared to previous methods. Also, the results show that the proposed method is more efficient in the neural stem cell category than in other categories. This method can be a good alternative to invasive methods including surgery.