A review of the changes of some cardiac inflammatory markers in obesity and the role of High Intensity Interval Training on them
Subject Areas : Physical Activity and Health
1 - گروه تربیت بدنی، واحد سنندج، دانشگاه آزاد اسلامی، سنندج، ایران.
Keywords: Intense exercise, obesity, cardiac tissue, TNF-&alpha, , IL-6 and CRP,
Abstract :
Background: Lack of physical activity, and high-fat diets have made overweight and obesity one of the major health problems. The increase of inflammatory factors following obesity is one of the main causes of mortality. Obesity is the cause of increasing fat storage and changing the function of fat cells. The metabolic effects of inflammation, which include insulin insensitivity, hyperlipidemia, muscle protein loss, acute hepatitis, protein synthesis, and oxidative stress, are regulated by proinflammatory cytokines. Considering the strong relationship between inflammatory indicators and the prevalence of various diseases, especially cardiovascular diseases, that any factor that reduces inflammatory indicators can reduce the probability of cardiovascular events. Meanwhile, today the positive effects of exercise and physical activity for the primary and secondary prevention of cardiovascular diseases have been correctly proven. According to this, physical activity can probably reduce the cardiovascular risk factors of people through the reduction of inflammatory, coagulation, body fat and obesity indicators, in these people. Methods: This purpose was carried out in all databases, especially Science of Web, Pubmed, Google scholar, Exercise training, Metabolic disorders, keywords with Mageiran, SID.IR, scholar risk factors, etc., without limitation of the year of search. Then the articles were categorized based on exercise training in metabolic disorders. Findings: The results show that intense exercise improves the inflammatory process that is disturbed by obesity and reduces the damage caused by obesity. Results: Disturbance of balance in obesity can have different effects of local and systemic inflammation and can play a role in metabolic disorders and complications of obesity. The results show that intense intermittent exercise increased TNF-α, IL-6 and CRP in the heart tissue of obese rats. Key words: Intense exercise, obesity, cardiac tissue, TNF-α, IL-6 and CRP
