A review on the application of multi-component reactions in the synthesis of pharmaceutical heterocyclics
Subject Areas : Polymers and Organic Structures
Samira
Arab-Salmanabadi
1
(Department of Chemistry, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran)
Keywords: Pharmaceutical heterocyclics, Multi Component Reactions, Pharmaceutical Chemistry, Cyclization reactions,
Abstract :
Most of the chemical drugs that have been used recently have been designed, identified, and manufactured by organic-pharmacological chemists through various chemical reactions. Multicomponent reactions (MCRs) as an evolving process have played an effective role in the synthesis of various drug compounds and the production of various molecules and heterocycles. The chances of producing new drugs increase through different methods of synthesis and study of the biological properties of synthetic derivatives. In recent years, the synthesis of new drugs and the study of various variables to optimize the production process of various chemical compounds with diverse functional groups, which can be the source of various biological activities, has been a very significant topic in the field of organic-medicinal chemistry. So far, extensive research has been conducted on the synthesis of new heterocycles with the aim of drug studies. In this review article, an attempt has been made to compile and present a set of researches in the field of design and synthesis of heterocycles with medicinal properties, focusing on the use of multi-component reactions.
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