Effect of hydroalcoholic extract of Ocimum basilicum on anxiety in male rats
Subject Areas : biology
زهرا
رنجبر فردویی
1
(دانشجو)
Nasrin
Heidarieh
2
(Member Azad University Qom)
Fatemeh
Jamallo
3
(Member Azad University Qom)
Keywords: evaluated maze, Anxiety, Rat, Ocimumbasilicum extract,
Abstract :
Introduction:Anxiety is a common disorder that often associated with the physiological symptoms such as heart rate , chest pain, shortness of breath. The use of medicinal plants has increased and the aim of this study was to evaluate the effect of hydro-alcoholic extracts of Ocimum basilicum on anxiety in male rats.Methods: Ocimumbasilicum leafy branches Having identified by herbarium University, hydro-alcoholic extract by Soxhlet extraction, and powdered extracts were prepared.. In this study the male Wistar rats(230±20g) were divided to intact group ,DMSO recipient( solvent extraction) group And receiving doses of 250, 50, 25, 15 mg / kg,( i.p) of Hydro-alcoholic extract.A half hours after injection, by Using the evaluated maze, the anxiety test was taken and the standard indicators of anxiety,( duration of stay and the number of entry into the open arm ) was recorded and checked for 5 minutes.ANOVA and Tukey test was used for analyzing data (P<0.05)Results: The results showed that the DMSO with compared to intact group had no effect on anxiety indicators. The Ocimumbasilicumhydroalcoholic extract at a dose of 25,15 mg / kg Compared to the group receiving DMSO, the time of stay in open arms and number of entry into open arm had a significant increase (p<0.001)Conclusion Ocimumbasilicum extract has anti-anxiety effect.Keywords: Ocimumbasilicum extract;anxiety; evaluated maze; rat
