Effect of folic acid on catalepsy in reserpine –induced parkinsonian male rat model
Subject Areas : zoologyFatemeh Tayebi 1 , رامش احمدی 2
1 - . M.Sc.student, Islamic Azad University
2 - هیئت علمی دانشگاه أزاد اسلامی واحد قم
Keywords: Parkinson, reserpine, bar-test, Rat, Keywords: Folic acid,
Abstract :
AbstractIntroduction: Experimental evidence suggests that the folate deficiency and its consequent, the elevated homocysteine level ,can sensitize the dopaminergic neurons of substantia nigra to the environmental toxin, whereby it may increase the risk of Parkinson disease. Parkinson's disease is a progressive neurological disorder with symptoms such as rest tremor, muscle stiffness, paucity of voluntary movements, and postural instability. Regarding the neuroprotective and antioxidant effect of the folic acid, purpose of this study was to determine the effect of folic acid on motor activity (catalpsy) in Parkinson model of rats with using the bar-test. Materials and Methods: In this experimental study, 24 rats were randomly divided into four groups. Experimental model of Parkinson's disease was induced by intraperitoneal injection of reserpine. Each of animals in the folic acid groups was given folic acid(5 mg / kg, i.p) every day. Then all groups were evaluated by the bar-test.Results: The results showed that this dose of the folic acid (5 mg / kg) for a week significantly(p <0/05) improves the catalepsy in the rats model of Parkinson's disease.Conclusion: It can be said that folic acid improves catalepsy in Rats Model of Parkinson's disease.
