Effect of phenylbutazone on the duration of various parameters after anesthesia induced by thiopental sodium in male dogs

Subject Areas : Journal of Comparative Pathobiology

مهدیه  رئیس زاده ¹ (ندارد)
حمید  رجائیان ² (ندارد)
حمیدرضا  فتاحیان ³ (ندارد)

Received: 2012-09-08 Accepted : 2012-12-18 Published : 2013-02-19

Keywords: Anesthesia, Drug Interaction, Phenylbutazone, Thiopental Sodium, Male Dog,

Abstract :

Taking drug interactions into consideration is an important aspect of therapy and being aware ofsuch interactions may help to achieve an effective treatment. The purpose of this research was toinvestigate the possible interaction between phenylbutazone and sodium thiopental in maledogs. Twenty one mixed breed dogs were randomly divided into two control and experimentalgroups. Normal saline and sodium thiopental were intravenously administered to animals in thecontrol group. Equivalent dose of sodium thiopental was administered following the injection ofphenylbutazone via the same route. After anesthesia, time intervals needed for the return ofpulpebral reflex, opening of eyes, tongue movement, extension of the limbs, head and neckmovement, sitting position, trying to stand, imbalanced walking, and normal walking wererecorded. Results show that, the average time periods in the experimental group were generallymore than those in the control group. It was also shown that the duration of the aboveparameters were significantly higher in heavier dog (>18kg) compared to the lighter ones(<18kg). It is generally concluded that simultaneous administration of sodium thiopental andphenylbutazone causes an increase in the recovery period for anesthesia. This may be due to anincrease in the unbound form of thiopental and a quicker distribution of the drug into the brainand, the refore, a greater duration of thiopental action.