Investigating the Effect of Induced Diabetes Model on Traditional and Non-Traditional lipid Indicators (T&NT),TyG Biomarker and CHG Index in Wistar rat

Subject Areas : Histology

mina arjmandi ¹ , seyed morteza razaghimanesh ² , Zahra Sadeqian ³ , Fateme Homayoon ⁴

1 - Doctor of Veterinary Medicine Graduate, Department of Veterinary Medicine Sho.C., Islamic Azad University, Shoushtar, Iran
2 - Department of Veterinary Clinical Sciences Sho.C., Islamic Azad University, Shoushtar, Iran
3 - Doctor of Veterinary Medicine Student, Department of Veterinary Medicine Sho.C., Islamic Azad University, Shoushtar, Iran
4 - Doctor of Veterinary Medicine Student, Department of Veterinary Medicine Sho.C., Islamic Azad University, Shoushtar, Iran

Received: 2025-09-22 Accepted : 2025-10-24 Published : 2025-11-15

Keywords: Induced diabetes, traditional and non-traditional lipid indicators, TyG index, CHG index, Wistar rat,

Abstract :

 This study was conducted to investigate the effect of a new and comprehensive combined model of diabetes on lipid and metabolic indices. In this study, 8 rats were randomly divided into two equal groups: healthy control and diabetic control. After 21 days of diabetes induction in the diabetic control group, blood lipid panel indices including; LDL cholesterol, HDL cholesterol, triglycerides and total cholesterol were measured in both groups. According to the results; In the diabetic control group compared to the healthy control group, there was an increase in the mean values ​​of traditional lipid indices including total cholesterol (TC), triglyceride (TG), LDL cholesterol and VLDL_C, which was not significant (P>0.05). There was a decrease in the mean values ​​of  HDL cholesterol index, which was not significant (P>0.05). There was an increase in the mean values ​​of non-traditional lipid indices, which was not significant in CRI-Ⅰ, CRI-Ⅱ, AC, TG/HDL ratio and RC indices (P>0.05), and it was significant in AIP, Non_HDL, ACI and RC/HDL ratio indices (P˂0.05). There was an increase in the mean values ​​of TyG and CHG indices, which was significant (P˂0.05). Induction of diabetes leads to disruption of the blood lipid panel and combined metabolic indices and atherogenic dyslipidemia, and subsequently the risk of micro- and macrovascular complications and resulting atherosclerotic cardiovascular diseases.

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