The Effect of a Period of Aerobic Exercise and Mesenchymal Stem Cells on Inflammatory Markers in Rats with Polycystic Ovary Syndrome
Subject Areas : Physical Activity and Health
sanaz miresmaeili
1
,
Abdolreza Jafari Chashmi
2
,
abdollah hashemvarzi
3
1 -
2 - Department of physical Education and Sports Science, Sari Branch, Islamic Azad University, Sari, Iran
3 - Department of physical Education and Sports Science, Sari Branch, Islamic Azad University, Sari, Iran
Keywords: Aerobic exercise, stem cells, inflammation, polycystic ovary syndrome,
Abstract :
Aim: The aim of the present study was to investigate the effect of aerobic exercise and stem cells on inflammatory markers in rats with polycystic ovary syndrome.
Method: In this experimental study, 30 adults female Wistar rats, 6-8 weeks old were divided into 6 groups after induction of PCOS: (1) healthy control (2) control-patient (3) patient-saline, (4) aerobic exercise-patient (5) stem cell-patient (6) aerobic exercise-stem cell-patient. Aerobic exercise groups performed 5 sessions of the desired exercises for eight weeks. Using an insulin syringe, about 1.5×106 extracted stem cells were injected into the tail vein of the patient mice. IL-6 and TNF-α levels were determined using a kit and ELISA method. Data analysis was performed using one-way analysis of variance and Tukey's post hoc test at a significance level of p<0.05.
Results: The findings of the study showed that IL-6 and TNF-α levels in the patient mice were significantly increased compared to the healthy control group (P<0.001). Aerobic exercise and stem cell therapy significantly reduced IL-6 and TNF-α levels in the exercise group compared to the control group (P<0.001).
Conclusion: Regular aerobic exercise and the use of stem cells as anti-inflammatory interventions may be able to reduce the levels of inflammatory factors TNF-α and IL-6 by increasing anti-inflammatory cytokines.
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