Numerical simulation and comparison of hepatic tumor hyperthermia using microwave and radiofrequency waves
Subject Areas : Journal of Simulation and Analysis of Novel Technologies in Mechanical Engineering
Hamoon Pourmirzaagha
1
,
Parimah Salimi
2
1 -
2 -
Keywords: Liver, Tumors, Radiofrequency, Microwave,
Abstract :
In this study, the thermal ablation of liver tumors using radiofrequency (RF) and microwave (MW) energy was numerically investigated. Heat transfer within the tissue was simulated based on coupled electromagnetic and bioheat models, employing a realistic liver geometry in COMSOL Multiphysics. Unlike previous studies that primarily used simplified cylindrical models, this work utilized actual tissue structure to achieve a more accurate analysis of temperature distribution, electromagnetic field intensity, and the extent of necrosis. The results indicate that the highest degree of tumor cell destruction occurs in regions closest to the applicator, while both field intensity and temperature gradually decrease with distance, leading to reduced necrosis. The realistic model demonstrated greater accuracy in predicting local temperatures and thermal effects compared to simplified models. Based on the findings, to minimize unintended damage to surrounding healthy tissue, it is recommended to reduce the applied power (to 5 W for MW) and voltage (to 17 V for RF). These results can contribute to the optimization of non-invasive liver cancer treatments and the safer design of hyperthermia devices.
[1] Esmaeili, A., Hemami, R., Ghaffari, Y., & Abdollahi, S. (2022). A review on evaluation of natural polymers with the approach of drug delivery system using herbal plant microcapsules. Journal of Simulation and Analysis of Novel Technologies in Mechanical Engineering, 2(2), 65.
[2] Ghorbani, A., Shahriari, S., & Gholami, A. M. (2021). Investigation of cell biomechanics and the effect of biomechanical stimuli on cancer and their characteristics. Journal of Simulation and Analysis of Novel Technologies in Mechanical Engineering, 13(4), 67-79.
[3] Asgari, F., Minooei, A., Abdolahi, S., Shokrani Foroushani, R., & Ghorbani, A. (2021). A new approach using Machine Learning and Deep Learning for the prediction of cancer tumor. Journal of Simulation and Analysis of Novel Technologies in Mechanical Engineering, 13(4), 41-51.
[4] Mohammad, N. D., Hassan, F., & Mina, T. (2013). Cancer metastasis, genetic and microenvironmental factors of distant tissue: a review article.
[5] Chiriac, H., Petreus, T., Carasevici, E., Labusca, L., Herea, D. D., Danceanu, C., & Lupu, N. (2015). In vitro cytotoxicity of Fe–Cr–Nb–B magnetic nanoparticles under high frequency electromagnetic field. Journal of Magnetism and Magnetic Materials, 380, 13-19.
[6] Hervault, A., & Thanh, N. T. K. (2014). Magnetic nanoparticle-based therapeutic agents for thermo-chemotherapy treatment of cancer. Nanoscale, 6(20), 11553-11573.
[7] Callstrom, M. R., & Kurup, A. N. (2009). Percutaneous ablation for bone and soft tissue metastases—why cryoablation?. Skeletal radiology, 38, 835-839.
[8] Dodd, G. D., Soulen, M. C., Kane, R. A., Livraghi, T., Lees, W. R., Yamashita, Y., ... & Rhim, H. (2000). Minimally invasive treatment of malignant hepatic tumors: at the threshold of a major breakthrough. Radiographics, 20(1), 9-27.
[9] Kuang, M., Lu, M. D., Xie, X. Y., Xu, H. X., Mo, L. Q., Liu, G. J., ... & Liang, J. Y. (2007). Liver cancer: increased microwave delivery to ablation zone with cooled-shaft antenna—experimental and clinical studies. Radiology, 242(3), 914-924.
[10] Eslami, M., Mokhtarian, A., Pirmoradian, M., Seifzadeh, S. A., & Rafiaei, S. M. (2020). Designing and creating a virtual reality environment and a wearable glove with control and evaluation capability to rehabilitate patients.
[11] Paganini, A. M., Rotundo, A., Barchetti, L., & Lezoche, E. (2007). Cryosurgical ablation of hepatic colorectal metastases. Surgical oncology, 16, 137-140.
[12] Berjano, E. J. (2006). Theoretical modeling for radiofrequency ablation: state-of-the-art and challenges for the future. Biomedical engineering online, 5(1), 24.
[13] Haemmerich, D. (2010). Biophysics of radiofrequency ablation. Critical Reviews™ in Biomedical Engineering, 38(1).
[14] Strohbehn, J. W. (1983). Temperature distributions from interstitial RF electrode hyperthermia systems: theoretical predictions. International Journal of Radiation Oncology* Biology* Physics, 9(11), 1655-1667.
[15] Petryk, A. A., Giustini, A. J., Gottesman, R. E., Trembly, B. S., & Hoopes, P. J. (2013). Comparison of magnetic nanoparticle and microwave hyperthermia cancer treatment methodology and treatment effect in a rodent breast cancer model. International Journal of Hyperthermia, 29(8), 819-827.
[16] Coughlin, C. T. (2023). Prospects for interstitial hyperthermia. In Interstitial hyperthermia: physics, biology and clinical aspects (pp. 1-10). CRC Press.
[17] Stigliano, R. V. (2014). Development and validation of a treatment planning model for magnetic nanoparticle hyperthermia cancer therapy. Dartmouth College.
[18] Qian, G. J., Wang, N., Shen, Q., Sheng, Y. H., Zhao, J. Q., Kuang, M., ... & Wu, M. C. (2012). Efficacy of microwave versus radiofrequency ablation for treatment of small hepatocellular carcinoma: experimental and clinical studies. European radiology, 22, 1983-1990.
[19] Khokhlova, T. D., & Hwang, J. H. (2016). HIFU for palliative treatment of pancreatic cancer. Therapeutic Ultrasound, 83-95.
[20] Pillai, K., Akhter, J., Chua, T. C., Shehata, M., Alzahrani, N., Al-Alem, I., & Morris, D. L. (2015). Heat sink effect on tumor ablation characteristics as observed in monopolar radiofrequency, bipolar radiofrequency, and microwave, using ex vivo calf liver model. Medicine, 94(9), e580.
[21] Lu, D. S., Raman, S. S., Vodopich, D. J., Wang, M., Sayre, J., & Lassman, C. (2002). Effect of vessel size on creation of hepatic radiofrequency lesions in pigs: assessment of the “heat sink” effect. American Journal of Roentgenology, 178(1), 47-51.
[22] Yhamyindee, P., Phasukkit, P., Tungjitkusolmon, S., & Sanpanich, A. (2012, December). Analysis of heat sink effect in hepatic cancer treatment near arterial for microwave ablation by using finite element method. In The 5th 2012 Biomedical Engineering International Conference (pp. 1-5). IEEE.
[23] Ringe, K. I., Lutat, C., Rieder, C., Schenk, A., Wacker, F., & Raatschen, H. J. (2015). Experimental evaluation of the heat sink effect in hepatic microwave ablation. PloS one, 10(7), e0134301.
[24] Ma, Z. H., Wang, Y. P., Zheng, W. H., Ma, J., Bai, X., Zhang, Y., ... & Hua, X. D. (2020). Prognostic factors and therapeutic effects of different treatment modalities for colorectal cancer liver metastases. World Journal of Gastrointestinal Oncology, 12(10), 1177.
[25] Radmilović-Radjenović, M., Bošković, N., & Radjenović, B. (2022). Computational modeling of microwave tumor ablation. Bioengineering, 9(11), 656.
[26] Gorman, J., Tan, W., & Abraham, J. (2022). Numerical simulation of microwave ablation in the human liver. Processes, 10(2), 361.
[27] Liu, J., Gao, H., Wang, J., He, Y., Lu, X., Cheng, Z., & Wu, S. (2023). Recent research advances on simulation modeling of temperature distribution in microwave ablation of lung tumors. Computer Assisted Surgery, 28(1), 2195078.
[28] Curley, S. A. (2003). Radiofrequency ablation of malignant liver tumors. Annals of Surgical Oncology, 10, 338-347.
[29] Sazgarnia, A., Naghavi, N., Mehdizadeh, H., & Shahamat, Z. (2015). Investigation of thermal distribution for pulsed laser radiation in cancer treatment with nanoparticle-mediated hyperthermia. Journal of thermal biology, 47, 32-41.
[30] SAWMPA, S. A. (2021). Three-dimensional numerical study for hepatic tumor ablation using electric current and bioheat transfer.
[31] Gorman, J., Tan, W., & Abraham, J. (2022). Numerical simulation of microwave ablation in the human liver. Processes, 10(2), 361.
[32] Dahaghin, A., Emadiyanrazavi, S., Haghpanahi, M., Salimibani, M., Bahreinizad, H., Eivazzadeh-Keihan, R., & Maleki, A. (2021). A comparative study on the effects of increase in injection sites on the magnetic nanoparticles hyperthermia. Journal of Drug Delivery Science and Technology, 63, 102542.
[33] Maaref, Y., Pakravan, H. A., & Jafarpur, K. (2019). Numerical Analysis of the Heat Sink Effect of Blood Vessels on Hepatic Radiofrequency and Microwave Ablation. Modares Mechanical Engineering, 19(7), 1711-1720.