Preparation of Al2O3-SO3H and nano Al2O3-SO3H as a heterogeneous catalyst for the one-pot tree component synthesis of Hexahydroquinazolinone

Subject Areas :

Masoumeh mehrabi ¹ , asad allah farhadi ² , Neda Hasanzadeh ³ , Ali Kiasat ⁴

1 - Department of Chemistry, Khuzestan Science and Research Branch, Islamic Azad University, Ahvaz, Iran
2 - petroleum university of technology
3 -
4 - Department of Chemistry, College of Science, Shahid Chamran University, Ahvaz 61357-4-3169, I.R. Iran.

Received: 2025-04-02 Accepted : 2025-05-15 Published : 2025-05-20

Keywords: Heterogeneous Acid Catalysts, One-pot three-component Catalytic, Nano Al2O3-SO3H, Hexahydroquinazolinone, Aldehyde.,

Abstract :

An efficient and practical synthetic method has been developed for the preparation of hexahydroquinazolinone derivatives via a one-pot three-component catalytic reaction. The method involves the reaction of various aldehyde derivatives with urea and 1,3-cyclohexadiene in the presence of Al₂O₃-SO₃H and nano Al₂O₃-SO₃H, which serve as effective heterogeneous acid catalysts. These catalysts exhibited excellent performance under thermal conditions, affording the desired products in high purity and excellent yields within short reaction times. This process offers several notable advantages, including operational simplicity, minimal purification steps, and the use of inexpensive and readily available catalysts. Moreover, the products were easily purified by crystallization, and the catalysts proved to be reusable over multiple cycles without significant loss of catalytic activity or efficiency.

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