In vitro comparative survey of the effect of aqueous and alcoholic extracts of Rosa canina hips on Trichomonas vaginalis and Candida albicans
Subject Areas : MycologyYasaman Faghih Nasiri 1 , Azar Sabokbar 2 , zohreh momeni 3 , Somayeh Talebi 4
1 - MSc, Department of Microbiology, Faculty of Basic Sciences ,Karaj Branch, Islamic Azad University, Karaj, Iran.
2 - Associate Professor, Department of Microbiology, Faculty of Basic Sciences, Karaj Branch, Islamic Azad University, Karaj, Iran.
3 - Assistant professor, Department of Microbiology, Faculty of Basic Sciences, Karaj Branch, Islamic Azad University, Karaj, Iran.
4 - PhD, Department of Microbiology, Faculty of Basic Sciences, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran.
Keywords: Rosa canina L. hips, Candida albicans, Trichomonas vaginalis, plant extract, antimicrobial effects,
Abstract :
Candida albicans and Trichomonas vaginalis are two common microorganisms in human sexually transmitted diseases, and drug resistance is increasing. Plant extracts are a rich source of active compounds and play an important role in the prevention and treatment of infectious diseases. For this reason, the aim of the present study is to investigate the inhibitory effect of aqueous and alcoholic extracts of rosehip (Rosa canina L.) fruit on C. albicans and T. vaginalis in laboratory conditions and compare it with a commercial drug. The aqueous and alcoholic extracts of rosehip fruit used in this study were prepared experimentally using water and 96% ethanol soaking. The ability of these extracts to inhibit the growth of microorganisms was evaluated using the microdilution method and the results were compared using statistical software. The results of this study indicated that concentrations of 30, 15, 7.5, 3.8, and 1.88 mg/ml of aqueous extract inhibited the growth of Trichomonas vaginalis by 45, 37, 20, 11, and 2%, respectively, over a period of 24 hours. While the inhibition rate increased over a period of 48 hours. Also, based on the results, it was determined that the alcoholic and aqueous extracts of rosehip fruit are not suitable for inhibiting the growth of Candida albicans. The results of this study determined that the fruit of the Rosa canina L. hips with its phytochemical compounds can be considered as a potential alternative to chemical drugs in the treatment of infections caused by T. vaginalis, but no favorable results were observed in dealing with C. albicans.
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