The effect of eight weeks' resistance and high-intensity interval training on neuropilin-1 levels in aged obese male rats
Subject Areas : Exercise Physiology and Sport Sciencesmahin hosseinabadi 1 , Mostafa Teimouri Kheravi 2
1 - Assistant Professor, Department of Sports Sciences, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran.
2 - Master's degree in physical education majoring in: applied exercise physiology. Islamic Azad university Bajnoord unit. Iran.
Keywords: Resistance training, High-intensity interval training, Neuropolin-1, Obesity, Aging.,
Abstract :
In the present quasi-experimental study, 30 aged male Wistar rats with an average age of 20-22 months were purchased from the Ferdowsi University of Mashhad Animal Hospital. Rats were randomly divided into three equal groups: high-fat diet, high-fat diet and resistance training, and high-fat diet and high-intensity interval training. Resistance training consisted of eight weeks, five sessions per week of climbing a one-meter ladder with 26 steps. In the first week, the amount of weights attached to the rats was 30% of their body weight, which gradually increased to 200% of their body weight in the final week. The exercises were performed in three sets of four repetitions. Three minutes of rest were taken between sets and about 10 seconds of rest between repetitions. The high-intensity interval training program included swimming in a rodent pool for eight weeks, five sessions per week. The intensity range of swimming training was considered from low intensity (load between zero and three percent of body mass) to high intensity (load between 5 and 16 percent of body mass). Forty-eight hours after the last training session, blood was drawn at 8:00 a.m. The serum was used to measure blood marker levels. To ensure the significance of the difference between groups, one-way analysis of variance test and SPSS version 22 software were used. The results showed that the exercise activities in the present study were able to exert their protective effects through changes in serum levels of neuropilin-1. Exercise training is able to increase neuroplein-1 levels compared to the control group, indicating the benefits of such exercises in the aging and obesity process. Of course, no significant differences were found between the two exercise groups. Full confirmation of these results requires further research by examining other signaling pathways as well as other factors involved in this field.
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URL: http://ijem.sbmu.ac.ir/article-1-966-fa.html
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