Tumor interactional equation with biological and drug environment
Subject Areas : Biomedical Spectroscopy, Microscopy, Imaging, EndoscopyRoshanak Kian 1 , Mohammad Sadegh Zakerhamidi 2 , Neda Ebrahimpour 3
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Keywords: Spectroscopy, Biological environment, Cancerous tumor, Kamlet–Taft, Molecular interactions,
Abstract :
Today, chemotherapy is an aggressive form of chemical drug therapy meant to destroy cancerous tumors in the human body. Since human body system can be considered as solvent/biological environment, by obtaining effective interactional equations in anticancer drugs, real behavior interactional of these drugs in body environment can be predicted. To this end, spectroscopic technique is one of a promising investigative and diagnostic tool that can assist in uncovering the interactional equation of cancerous tumor and provide quantifiable molecular information for diagnosis and treatment evaluation. To investigate the interactional equation of cancerous tissues and the type of their interactional behavior, samples were taken from these tissues and the mathematical model of cancerous tissue interaction was presented using Kamlet–Taft polarity parameters. This equation probes anticancer drug molecular interactional reactions with cancerous tumors in a sample to obtain information on their effective coefficient in the body and/or inter/intra molecular interactions. These interactions contain detailed information about the behavior of drugs used in cancer treatment and cancer tissues, which can be very useful for choosing treatment methods.
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