Characterization and Toxicity Mechanism of Environmental Risk Factors (Heavy Metals) and Reproductive Health: A Review Paper
Subject Areas : Journal of Chemical Health Risks
Mohammad Reza Khaksar
1
,
Rahim Aali Dehchenari
2
,
Yadollah Ghafuri
3
1 -
2 -
3 -
Keywords: Toxicity, Environmental, Heavy metals, Reproductive health,
Abstract :
Environmental epidemiologic studies have identified many associations between human exposure to chemicals during pregnancy and maternal and child health outcomes. This study is a systematic review in which the impact of environmental hazards including kinetics and mechanisms of toxicity and ways of exposure to heavy metals on fetal health and fertility has been reviewed. Search in scientific sites and search engines including SID, Magiran, ScienceDirect, Google Scholar, PubMed, Springer and, Scopus have been done using the desired keywords along with the review of sources that have provided the impact of environmental factors on fetal health and fertility. Finding of this review study point to several evidences that prenatal maternal exposure to heavy metals is related to fetal epigenomic changes, direct effects on reproductive potential, retards of fetal growth and, other risks during pregnancy. Accordingly, to achieve preventative processes including assessment, diagnosis and, planning for health promotion during pregnancy, developing national preventive guidelines to reduce exposure to heavy metals during pregnancy is inevitable.
1. Abdollahi M., Khaksar M.R., 2023. Sodium Dimethyldithiocarbamate. Encyclopedia of Toxicology, 4nd ed. Elsevier. pp. 601-606.
2. Ghafuri Y., Nabizadeh R., 2017. Composition and quantity of cytotoxic waste from oncology wards: A survey of environmental characterization and source management of medical cytotoxic waste. Biosci Biotechnol Res Commun. 10(3),438-4.
3. Pajewska-Szmyt M., Sinkiewicz-Darol E., Gadzała-Kopciuch R., 2019. The impact of environmental pollution on the quality of mother's milk. Environmental Science and Pollution Research. 26,7405-27.
4. Pikounis T.D., Amann K.L., Jackson B.P., Punshon T., Gilbert-Diamond D., Korrick S., Karagas M.R., Cottingham K.L.,2024. Urinary biomarkers of exposure to toxic and essential elements: A comparison of infants fed with human milk or formula. Environmental Epidemiology. 8(1), e286.
5. Triche E.W., Hossain N., 2007. Environmental factors implicated in the causation of adverse pregnancy outcome. InSeminars in perinatology . 31(4), 240-242.
6]. Yurdakök K., 2015. Lead, mercury, and cadmium in breast milk. Journal of Pediatric and Neonatal Individualized Medicine (JPNIM).4(2),e040223
7. Jafarzadeh S, Fard RF, Ghorbani E, Saghafipour A, Moradi-Asl E, Ghafuri Y., 2020. Potential risk assessment of heavy metals in the Aharchai River in northwestern Iran. Physics and Chemistry of the Earth. Parts A/B/C.1;115,102812.
8. Mostafaii G., Bakhtyari Z., Atoof F., Baziar M., Fouladi-Fard R., Rezaali M., Mirzaei N., 2021. Health risk assessment and source apportionment of heavy metals in atmospheric dustfall in a city of Khuzestan Province, Iran. Journal of Environmental Health Science and Engineering. 19,585-601.
9. Soleimani A., Toolabi A., Mansour S.N., Abdolahnejad A, Akther T, Fouladi-Fard R., Miri M., Mohammadi A. 2024. Health risk assessment and spatial trend of metals in settled dust of surrounding areas of Lake Urmia, NW Iran. International Journal of Environmental Analytical Chemistry. 104(5),1172-85.
10. Khaksar M.R., Navaei-Nigjeh M., Daniali M., Rahimifard M., 2020. Multi-organ Toxicity Attenuation by Cerium Oxide and Yttrium Oxide Nanoparticles: Comparing the Beneficial Effects on Tissues Oxidative Damage Induced by Sub-Acute Exposure to Diazinon. Pharmaceutical Nanotechnology. 8, 1-14.
11. Pati D., Lorusso L.N., How to write a systematic review of the literature. HERD. 2018. Health Environments Research & Design Journal. 11(1),15-30.
12. Bommarito P.A., Martin E., Fry R.C., 2017. Effects of prenatal exposure to endocrine disruptors and toxic metals on the fetal epigenome. Epigenomics. 9(3), 333-50.
13. Gangopadhyay S., Sharma V., Chauhan A., Srivastava V., 2019. Potential facet for prenatal arsenic exposure paradigm: linking endocrine disruption and epigenetics. Nucleus. 62, 127–142 . https://doi.org/10.1007/s13237-019-00274-3
14. Freire C., Amaya E., Gil F., Murcia M., LLop S., Casas M., Vrijheid M., Lertxundi A., Irizar A., Fernández-Tardón G., Castro-Delgado R.V., 2019. Placental metal concentrations and birth outcomes: The Environment and Childhood (INMA) project. International Journal of Hygiene and Environmental Health. 222(3),468-78.
15. Bank-Nielsen P.I., Long M., Bonefeld-Jørgensen E.C., 2019. Pregnant inuit women’s exposure to metals and association with fetal growth outcomes. Int J Environ Res Public Health. 16(7). http://www.ncbi.nlm.nih.gov/pubmed/30939809
16. Sabra S., Malmqvist E., Saborit A., Gratacós E., Gomez Roig M.D., 2017. Heavy metals exposure levels and their correlation with different clinical forms of fetal growth restriction. PLoSOne. 12(10),e0185645. http://www.ncbi.nlm.nih.gov/pubmed/28985223
17. Punshon T., Li Z., Jackson B.P., Parks W.T., Romano M., Conway D., 2020. Placental metal concentrations in relation to placental growth, efficiency and birth weight. Environ Int .126,533–42. http://www.ncbi.nlm.nih.gov/pubmed/30851484
18. Qia J., Laia Y., Lianga C., Yanc S., Huanga K., Panc W., Fenga L., Jianga L., Zhua P., Haoa J., Tonga S., 2019. Prenatal thallium exposure and poor growth in early childhood: A prospective birth cohort study. Environment International. 123, 224–230.
19. Vilahur N., Vahter M., Broberg K., 2015. The Epigenetic Effects of Prenatal Cadmium Exposure. Curr Envir Health Rpt. 2,195–203.
20. Bansa1 D.K., Awua A.K., Boatin R., Adom T., Brown-Appiah1 E.C., Amewosina K.K., Diaba A., Datoghe D., Okwabi W., 2017. Cross-sectional assessment of infants’ exposure to toxic metals through breast milk in a prospective cohort study of mining communities in Ghana. BMC Public Health. 17, 505,1-12.
21. Pikounis T.D., Amann K.L., Jackson B.P., Punshon T., Gilbert-Diamond D., Korrick S., Karagas M.R., Cottingham K.L., 2024. Urinary biomarkers of exposure to toxic and essential elements: A comparison of infants fed with human milk or formula. Environmental Epidemiology. 8(1), e286
22. Palmieri J.R., Meacham S. Brunette J., Miluski T., Dhanju S., Stein S., 2019. Effects heavy metal and organic contaminants during pregnancy and lactation on child health. J Clin Case Rep Trials. 2, 26-34.
23. Mulware S.J., 2020. Toxicity of Heavy Metals, A. Subject in Review. International Journal of Recent Research in Physics and Chemical Sciences. 6(2), 30-43.
24. Al O., Ex F., R P., I B.M., I S., 2023. Heavy Metal Toxicity: A Potential Risk Factor for Autism. Journal of Experimental and Basic Medical Sciences.4(3),192-6.
25. Manfol F.P., Nantia E.A., Wang K., Moundipa P.F., Mathu P.P., 2014. Heavy Metal Induced Toxicity on Male Reproductive Function. Contemporary Topics in Life Sciences. 19,1-26.
26. Mobarak Y., 2008. Review of the developmental toxicity and teratogenicity of three environmental contaminants (cadmium, lead and mercury). Catrina: The International Journal of Environmental Sciences. 3(1),31-43.
27. Baser E., kırmızı D.A., Turksoy V.A., Onat T., Çaltekin M.D., Kara M., Yalvac E.S.,2020. Environmental Exposures in the Etiology of Abortion: Placental Toxic and Trace Element Levels. Zeitschrift für Geburtshilfe und Neonatologie. 224(06), 339-347.
28. Dong X., Ding A., Hu H., Xu F., Liu L., Wu M., 2023. Placental barrier on cadmium transfer from mother to fetus in related to pregnancy complications. International Journal of Women's Health. 179-190.
29. Windham G., Fenster L., 2008. Environmental contaminants and pregnancy outcomes. Fertility and sterility. 89(2),e111-6.
30. Jaishankar M., Tseten T., Anbalagan N., Mathew B.B., Beeregowda K.N., 2014. Toxicity, mechanism and health effects of some heavy metals. Interdiscip Toxicol. 7(2), 60–72.
31. Magelsir H.M., 2016. Heavy metal toxicity-metabolism, absorption, distribution, excretion and mechanism of toxicity for each of the metals. World News of Natural Sciences. (4),20-32.
32. Egorova K.S., Ananikov V.P., 2017. Toxicity of metal compounds: knowledge and myths. Organometallics. 36(21),4071-90.
33. Srnovršnik T., Virant-Klun I., Pinter B., 2023. Heavy Metals and Essential Elements in Association with Oxidative Stress in Women with Polycystic Ovary Syndrome, A Systematic Review. Antioxidants. 12, 1398. https://doi.org/10.3390/antiox12071398
34. A. Antar S., Halouani A., Gad C., Al-Karmalawy A., 2024. An Overview of the Mechanisms of Cadmium-Induced Toxicity in the Male Reproductive System. Pharmaceutical Sciences. 30(1), 36-53.
35. Gómez-Roig M.D., Pascal R., Cahuana M.J., García-Algar O., Sebastiani G., Andreu-Fernández V., Martínez L., Rodríguez G., Iglesia I., Ortiz-Arrabal O., Mesa M.D., 2021. Environmental exposure during pregnancy: influence on prenatal development and early life: a comprehensive review. Fetal diagnosis and therapy. 48(4),245-57.
36. Guimarães M.T., Cunha M.G., Carvalho D.P., Ribeiro T.S., Martins L.C., Braga A.L., Pereira L.A., 2015. Influence of environmental contamination on pregnancy outcomes. Environmental Science and Pollution Research. 22, 14950-9.
37. Kamai E.M., McElrath T.F., Ferguson K.K., 2019. Fetal growth in environmental epidemiology: mechanisms, limitations, and a review of associations with biomarkers of non-persistent chemical exposures during pregnancy. Environmental Health. 18,1-30
