The effect of hydroalcoholic Melissa officinalis extract on fractional shortening in rats

Subject Areas : Veterinary Clinical Pathology

Ramin Bahramnejad Heris ¹ , Gh. Assadnassab, ²

1 - DVM
2 - Department of Clinical Science, Tabriz Branch, Islamic Azad University, Tabriz, Iran

Received: 2024-06-22 Accepted : 2024-09-11 Published : 2025-03-03

Keywords: Echocardiography, Fractional shortening, Melissa officinalis, Rat,

Abstract :

Melissa officinalis is one of the medicinal plants. In this study, the hydroalcoholic extract of Melissa officinalis effect on fractional shortening in the rat animal model was determined. To conduct this study, standard echocardiography was performed in all 40 male rats, and fractional shortening was determined. The animals were randomly divided into four groups. The first was control group and the second to fourth groups were administered with the intraperitoneal injection of Melissa officinalis extract daily for 21 days with doses of 100, 200 and 400 mg per kg body weight of rat. The animals were subjected to echocardiography on days 7, 14 and 21 after administration, and the fractional shortening was calculated. The means of fractional shortening in the fourth group showed the highest increase with an average of 34.74 ± 1.8%, and the highest dose on the last day showed a significant difference with other groups under study (p < 0.05). But within the fourth group, the means of the fractional shortening data of the seventh day and the fourteenth day did not have significant changes (p<0.05). This study shows the increasing effect of fractional shortening following the administration extract in different doses, and it can also be seen with the passage of time. But this increase can be seen only at a highest dose and even at a longest time of administration, which can be caused by the effect of this particular dose in the conditions under study. Conflict of interest: None declared.

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