Application of Box-Behnken Method for Optimization and Modeling of 1,5 –Benzodiazepine Production Reaction by CuFe2O4/Clinoptilolite Nanocatalyst

Subject Areas : Applied Mathematics Modeling

Nazanin Gholamrezaeenya ¹ (Department of Chemistry, Arak Branch, Islamic Azad University, Arak, I.R. IRAN)
Kazem Mahanpoor ² (Department of Chemistry, Faculty of science, Arak Branch, Islamic Azad University, Arak, Iran)
Keivan Ghodrati ³ (Department of Chemistry, Kermanshah Branch, Islamic Azad University, Kermanshah,. I.R. IRAN)
Azam Marjani ⁴ (گروه شیمی، دانشکده علوم پایه، واحد اراک، دانشگاه آزاد اسلامی، اراک، ایران)
Masoomeh Abdoli-Senejani ⁵ (Department of chemistry, Islamic azad university, Arak branch)

Received: 2023-06-15 Accepted : 2023-06-15 Published : 2023-06-15

Keywords: Box-Behnken, Optimization, 1, 5-Benzodiazepine, CuFe2O4/Clinoptilolite ,

Abstract :

In this study, the Box-Behnken design (BBD) was used in the response surface method (RSM) to investigate the modeling and optimization parameters in the synthesis of a 1,5-Benzodiazepine. This method was used to optimize the influencing factors in the synthesis process of this material, including the amount of nanocatalyst, temperature, and reaction time. The obtained mathematical model was analyzed by variance analysis. To determine the optimal conditions, graphs of graphic counters and response levels were used. The results showed that the amount of nanocatalyst has the greatest effect on the synthesis reaction of 1.5 Benzodiazepines. The maximum efficiency for the synthesis of the product was determined at a temperature of 283 K, the amount of CuFe2O4/Clinoptilolite = 6 g/lr and time = 60 minutes.

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