The effect of hypertonic and isotonic saline solutions on heart rate, electrocardiographic parameters, oxygen saturation concentration, and some serum electrolytes in healthy lambs and those with diarrhea

Subject Areas : Veterinary Clinical Pathology

Ali Ghasemizade Shahrabadi ¹ , Shahram Maleki ² , Amir Zakian ³ , Moein Yazdkhasti ⁴

1 - .V.M. Graduate, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran.
2 - Assistant Professor, Department of Clinical Sciences, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran.
3 - Assistant Professor, Department of Clinical Sciences, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran.
4 - Assistant Professor, Department of Clinical Sciences, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran.

Received: 2024-08-06 Accepted : 2024-12-30 Published : 2025-05-20

Keywords: Diarrhea, Electrocardiogram, Electrolyte, Hypertonic Serum, Isotonic Serum, Lamb. ,

Abstract :

Minerals are a group of nutrients that are essential and important in the animal's diet. Imbalance of electrolytes in animals is very dangerous. Therefore, the aim of this study was to investigate the effect of injection of hypertonic and isotonic solutions and their resuscitation capability on electrolyte balance. For this purpose, 42 lambs were randomly divided into 6 groups, with diarrhea induced in 3 groups using oral ORS powder. Blood samples were collected before fluid therapy and at 15, 60, and 120 minutes after treatment, and analyzed for hematological and serum biochemical parameters, as well as electrocardiographic changes. The results showed that hypertonic serum increased glucose concentration, lymphocyte count, and segmented neutrophils in lambs. Isotonic saline increased chloride and sodium levels in both healthy and diarrheic lambs. Electrocardiographic findings revealed no significant changes in wave intervals over time, except for the P-R segment, which increased in diarrheic lambs but decreased in healthy lambs after serum injection. This study demonstrates the importance of close monitoring of a wide range of health and performance parameters when evaluating fluid therapy interventions in lambs, as its effects can be complex and variable depending on the underlying conditions and treatment approach.