The effect of a period of high-intensity interval training and high dose of vitamin D on adiponectin and leptin levels in overweight women with low vitamin D levels
Subject Areas : Effect of Physical Activity on Diseases
roya zolfaghari
1
,
babisan askari
2
,
Iman Ghanbari
3
1 - 1. Department of Physical Education and Sport Sciences, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran.
2 - Assistant Professor, Department of Physical Education and Sport Sciences, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran.
3 - assistant professor
Keywords: Adipokine, leptin, Interval training, Vitamin D,
Abstract :
Background and Purpose: Leptin and adiponectin are adipokines, which play an important role in regulating inflammation and metabolism, are affected by weight gain and vitamin D deficiency. The purpose of this study is to investigate the effect of high-intensity interval training and high dose of vitamin D on adiponectin and leptin levels in overweight women with low vitamin D levels. Material and Methods: In this experimental study, 26 overweight and vitamin D deficient women were randomly divided into control, exercise + vitamin D groups after being selected using the available sampling method. High-intensity interval running training consisted of one-minute sprint with an intensity of 80-90% of the maximum heart rate in 6 to 12 repetitions, along with a one-minute active rest with an intensity of 50% of the maximum heart rate. Vitamin D was taken at a dose of 50,000 units weekly. Data analysis was done using one-way ANOVA test (p≥0.05). Results: The results showed that high-intensity running training and vitamin D consumption led to a significant difference in the levels of leptin, adiponectin and 25-hydroxyvitamin D in the experimental group. Also, there was a significant and inverse relationship between the level of 25-hydroxyvitamin D with body mass index and leptin levels, as well as a significant and direct relationship with adiponectin levels in the baseline condition. Conclusion: It seems that performing high-intensity running exercise and high dose of vitamin D consumption can increase health by modulating leptin and adiponectin in overweight conditions with vitamin D deficiency in young women.
1. Carvalho-Rassbach M, Alvarez-Leite JI, de Fátima Haueisen Sander Diniz M. Is the association between vitamin D, adiponectin, and insulin resistance present in normal weight or obese? A pilot study. Clinical Nutrition Experimental 2019;23:80-88.
2. Vainio H, Kaaks R, Bianchini F. Weight control and physical activity in cancer prevention: international evaluation of the evidence. European Journal of Cancer Prevention 2002; Suppl 2:S94-100.
3. Klöting N, Fasshauer M, Dietrich A, Kovacs P, Schön MR, Kern M, et al.Insulin-sensitive obesity. American Journal of Physiology-Endocrinology and Metabolism 2010;299:E506-15.
4. Blumberg JM, Tzameli I, Astapova I, Lam FS, Flier JS, Hollenberg AN. Complex role of the vitamin D receptor and its ligand in adipogenesis in 3T3-L1 cells. Journal of Biological Chemistry 2006;281(16):11205-13.
5. Forny-Germano L, De Felice FG, Vieira MNDN. The Role of Leptin and Adiponectin in Obesity-Associated Cognitive Decline and Alzheimer's Disease. Frontiers in Neuroscience 2019;12:1027.
6. Liu Y, Palanivel R, Rai E, Park M, Gabor TV, Scheid MP, et al. Adiponectin stimulates autophagy and reduces oxidative stress to enhance insulin sensitivity during high-fat diet feeding in mice. Diabetes 2015; 64:36-48.
7. Szymczak-Pajor I, Miazek K, Selmi A, Balcerczyk A, Śliwińska A. The Action of Vitamin D in Adipose Tissue: Is There the Link between Vitamin D Deficiency and Adipose Tissue-Related Metabolic Disorders? nternational journal of molecular sciences 2022;23(2):956.
8. Ahima RS, Lazar MA. Adipokines and the peripheral and neural control of energy balance. Journal of molecular endocrinology 2008;22:1023-1031.
9. Murawska-Ciałowicz E, Kaczmarek A, Kałwa M, Oniszczuk A. Influence of Training and Single Exercise on Leptin Level and Metabolism in Obese Overweight and Normal-Weight Women of Different Age. International Journal of Environmental Research and Public Health 2022;19(19):12168.
10. Holick MF, Chen TC. Vitamin D deficiency: A worldwide problem with health consequences. American Journal of Clinical Nutrition 2008;87:1080S‑6S.
11. Khosravi ZS, Kafeshani M, Tavasoli P, Zadeh AH, Entezari MH. Effect of vitamin D supplementation on weight loss, glycemic indices, and lipid profile in obese and overweight women: a clinical trial study. International journal of preventive medicin 2018;9:63.
12. Gannagé-Yared MH, Chedid R, Khalife S, Azzi E, Zoghbi F, Halaby G. Vitamin D in relation to metabolic risk factors, insulin sensitivity and adiponectin in a young Middle-Eastern population. European journal of endocrinology 2009;160(6):965-71.
13.Vaidya A. Vitamin D and cardiometabolicdisease. Metabolism 2013; 62:1697–9.
14. Wasiluk, D, Stefańska, E, Ostrowska, L, Serwin, A.B, Klepacki, A, Chodynicka, B. Nutritive value of daily food rations of patients with psoriasis vulgaris: A preliminary report. Advances in Dermatology and Allergology 2012; 5:348-55.
15. Mousa A, Naderpoor N, Wilson K, Plebanski M, De Courten MPJ, Scragg RD , et al. Vitamin D supplementation increases adipokine concentrations in overweight or obese adults. European journal of nutrition 2019, 59, 195-204.
16. angloff A, Bergeron J, Lemieux I, Tremblay A, Poirier P, Alméras N, et al. Relationships between circulating 25(OH) vitamin D, leptin levels and visceral adipose tissue volume: results from a 1-year lifestyle intervention program in men with visceral obesity. The International Journal of Obesity 2020;44(2):280-288.
17. Bray GA, Frühbeck G, Ryan DH, Wilding JP. Management of Obesity. Lancet 2016; 387(10031):1947–56.
18. Morze J, Rücker G, Danielewicz A, Przybyłowicz K, Neuenschwander M, Schlesinger S, et al. Impact of Different Training Modalities on Anthropometric Outcomes in Patients With Obesity: A Systematic Review and Network Meta-Analysis. Obesity Reviews 2021; 22(7):e13218.
19. O'Donoghue G, Blake C, Cunningham C, Lennon O, Perrotta C. What Exercise Prescription Is Optimal to Improve Body Composition and Cardiorespiratory Fitness in Adults Living With Obesity? A Network Meta-Analysis. Obesity Reviews 2021; 22(2):e13137.
20. Yu N, Ruan Y, Gao X, Sun J. Systematic Review and Meta-Analysis of Randomized, Controlled Trials on the Effect of Exercise on Serum Leptin and Adiponectin in Overweight and Obese Individuals. Hormone and Metabolic Research 2017;49(3):164-173.
21. Lopes WA, Leite N, da Silva LR, Brunelli DT, Gáspari AF, Radominski RB, et al. Effects of 12 Weeks of Combined Training Without Caloric Restriction on Inflammatory Markers in Overweight Girls. Journal of sports science 2016;34 (20):1902-12.
22. Kolahdouzi S, Baghadam M, Kani-Golzar FA, Saeidi A, Jabbour G, Ayadi A, et al. Progressive Circuit Resistance Training Improves Inflammatory Biomarkers and Insulin Resistance in Obese Men. Physiology and behavior 2019; 205:15-21.
23. Nunes PRP, Martins FM, Souza AP, Carneiro MAS, Orsatti CL, Michelin MA, et al. Effect of High-Intensity Interval Training on Body Composition and Inflammatory Markers in Obese Postmenopausal Women: A Randomized Controlled Trial. Menopause 2019;26(3):256-64.
24. Akbari R, Jafari Chashmy A, Habibian M. 'The effect of eight weeks of high-intensity interval resistance training on serotonin 1 and 25-hydroxyvitamin D levels in overweight women with vitamin D deficiency', Daneshvar Medicine 2022; 30(4):74-83.25.
25. Poon ETC, Siu PMF, Wongpipit W, Gibala M, Wonga SHS. Alternating high-intensity interval training and continuous training is efficacious in improving cardiometabolic health in obese middle-aged men. Journal of Exercise Science & Fitness 2022;20(1):40-47.
26. Karonova T, Belyaeva O, Jude EB, Tsiberkin A, Andreeva A, Grineva E, et al. Serum 25(OH)D and adipokines levels in people with abdominal obesity. Journal of Steroid Biochemistry and Molecular Biology 2018;175:170-176.
27. Vilarrasa N, Vendrell J, Maravall J, Elío I, Solano E, San José P, et al. Is plasma 25(OH) D related to adipokines, inflammatory cytokines and insulin resistance in both a healthy and morbidly obese population? Endocrine. 2010 Oct;38(2):235-42.
28. de Souza WN, Norde MM, Oki É, Rogero MM, Marchioni DM, Fisberg RM, et al. Association between 25-hydroxyvitamin D and inflammatory biomarker levels in a cross-sectional population-based study, São Paulo, Brazil. Nutrition research reviews 2016;36(1):1-8.
29. Khademi Z, Hamedi-Shahraki S, Amirkhizi F. Vitamin D insufficiency is associated with inflammation and deregulation of adipokines in patients with metabolic syndrome. BMC endocrine disorders 2022;22(1):223.
30. Sirico F, Bianco A, D'Alicandro G, Castaldo C, Montagnani S, Spera R, et al. Effects of Physical Exercise on Adiponectin, Leptin, and Inflammatory Markers in Childhood Obesity: Systematic Review and Meta-Analysis. Childhood obesity 2018;14(4):207-17.
31. Najafi M, Fatolahi H. The Effect of Resistance Training and Vitamin D on Leptin and HDL-C in Overweight Women. International Journal of Sport Studies for Health 2020;3(1):e104742.
32. Sundari LPR, Bakta M, Astawa NM, Adiatmika PG, Arijana GKN, Tunas K. The Effect of Vitamin D Administration on Leptin, Adiponectin and mRNA MCP-1 Levels in Adipose Tissue of Obese Female Wistar Rats. Current Research in Food Science 2020; 8(2):541-49.
33. Gharekhani A, Najafipour F, Baradaran H, Tagharrobi P, Rezaee H. The Effect of Treating Vitamin D Deficiency or Insufficiency on Serum Adiponectin, Leptin and Insulin Resistance of Type 2 Diabetes Mellitus Patients: A Pilot Study. Iranian Journal of Pharmaceutical Research 2020;19(3):86-94.
34. Bahrami K, Shahdadi A. The Effect of Aerobic Exercise on Serum Leptin Levels and Body Mass Index in Obese Young Girls. Qom University of Medical Sciences journal 2015; 9 (6) :27-36
35. Hemmati Shekarab S, Siahkouhian M, RahbarghaziA. The effect of 6 weeks of aerobic, resistance and combination training on serum leptin levels and cardiovascular risk factors in inactive obese girls. Medical journal of mashhad university of medical sciences 2022; 65(4):1486-1501.
36. Küçük Yetgin M, Agopyan A, Küçükler FK, Gedikbaşı A, Yetgin S, Çelik Kayapınar F, et al. The Effects of Resistance and Aerobic Exercises on Adiponectin, Insulin Resistance, Lipid Profile and Body Composition in Adolescent Boys with Obesity. Istanbul Medical Journal 2020; 21(3): 182-9.
37. Shoaei Makanet S, gholami M, Soheili S, Ghazalian F. ('The effect of eight weeks aerobic training and omega3 ingestion on the levels of CTRP-9 and adiponectin in overweight and obese women', Razavi International Journal of Medicine 2023; 11(1); e1015.
38. Hejazi K, Wong A. Effects of exercise training on inflammatory and cardiometabolic health markers in overweight and obese adults: a systematic review and meta-analysis of randomized controlled trials. The Journal of sports medicine and physical fitness 2023;63(2):345-359.
39. Ouerghi N, Fradj MKB, Duclos M, Bouassida A, Feki M, Weiss K, et al. Effects of High-Intensity Interval Training on Selected Adipokines and Cardiometabolic Risk Markers in Normal-Weight and Overweight/Obese Young Males-A Pre-Post Test Trial. Biology (Basel) 2022;11(6):853.
40. Wang S, Zhou H, Zhao C, He H. Effect of Exercise Training on Body Composition and Inflammatory Cytokine Levels in Overweight and Obese Individuals: A Systematic Review and Network Meta-Analysis. Frontiers in immunology 2022;13:921085.
41. Aktaş HŞ, Uzun YE, Kutlu O, Pençe HH, Özçelik F, Çil EÖ, et al. The effects of high intensity-interval training on vaspin, adiponectin and leptin levels in women with polycystic ovary syndrome. Archives of Physiology and Biochemistry 2022;128(1):37-42
42. Gonzalez-Lopez L, Fajardo-Robledo NS, Miriam Saldaña-Cruz A, Moreno-Sandoval IV, Bonilla-Lara D, Zavaleta-Muñiz S, et al. Association of adipokines, interleukin-6, and tumor necrosis factor-α concentrations with clinical characteristics and presence of spinal syndesmophytes in patients with ankylosing spondylitis: A cross-sectional study. International journal of medical research 2017;45(3):1024-1035.
43. Asad M, Ravasi AA, Faramarzi M, Pournemati P. The effects of three training methods endurance, resistance and concurrent on adiponectin resting levels in overweighed untrained men. Bratislavske lekarske listy 2012; 113: 664-668.
44. Bouassida A, Chamari K, Zaouali M, Feki Y, Zbidi A, Tabka Z. Review on leptin and adiponectin responses and adaptations to acute and chronic exercise. British journal of sports medicine 2010; 44: 620-630.
45. Fedewa MV, Hathaway ED, Ward-Ritacco CL, Williams TD, Dobbs WC. The Effect of Chronic Exercise Training on Leptin: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Sports Medicin 2018;48(6):1437-1450.
