Understanding the Different pathways of programmed cell death in the targeted therapy of diseases
Subject Areas : Developmental biology of plants and animals , development and differentiation in microorganisms
amir arasteh
1
,
Morteza Karimpour
2
,
Faezeh Fallah
3
,
Sara Kiani
4
1 - Department of biology, Rasht branch, Islamic Azad University, Rasht, Iran
2 - Department of biology, Islamic Azad University of Rasht branch
3 - Department of biology, Central Tehran branch, Islamic Azad University, Tehran, Iran
4 - Department of biology, Central Tehran branch, Islamic Azad University, Tehran, Iran
Keywords: Keywords: Apoptosis, Signaling pathways, Caspase, Cancer,
Abstract :
Abstract Developing therapies that promote the efficient death of cancer cells by apoptosis has been a cornerstone and goal of clinical oncology for over thirty years. Multiple signaling pathways, known as intrinsic and extrinsic, are involved in the process of programmed cell death. These pathways are activated by various stimuli such as immune surveillance, DNA damage and cellular stress. Cell death may also be influenced by how apoptotic pathways interact with other signaling processes. Drug discovery studies (Addressing bioavailability, stability, tumor penetration, toxicity profile in non-malignant tissues, drug interactions, and off-target effects) and an understanding of tumor biology are essential for the clinical translation of effective pro-apoptotic agents. Tumor cell death is possible with therapeutic methods, but the selection, growth and proliferation of resistant cells ultimately determine the lethality potential. The present study aimed to investigate the early apoptosis pathways and the related signaling pathways, along with discussing their molecular targets in terms of therapy.
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