The Effects of 8 Weeks Aerobic Exercise Training on Serum levels of Myonectine and Insulin Resistance in Obese and Overweight Women

Subject Areas : Sport Sciences Quarterly

khatereh naderipoor ¹ , abdoreza kazemi ²

1 - کارشناسی ارشد فیزیولوژی ورزشی، گروه تربیت بدنی، دانشکده ادبیات و علوم انسانی، دانشگاه آزاد اسلامی، کرمان، ایران
2 - دانشیار گروه علوم ورزشی، دانشکده ادبیات و علوم انسانی، دانشگاه ولی عصر (عج)، رفسنجان، ایران.

Received: 2022-02-15 Accepted : 2022-02-15 Published : 2021-11-22

Keywords: obese women, Myonectin insulin resistance,

Abstract :

AbstractObesity is related to cardiovascular diseases, metabolic syndrome, diabetes, and insulin resistance in overweight and obese women. Myonectin is a myokine that is generally secreted from skeletal muscle and inversely associated with obesity. The aim of the present study was to investigate the effects of 8 weeks of aerobic training on serum levels of Myonectine and insulin resistance in obese and overweight women. In this study 21 obese women were allocated to exercise and control groups. Exercise training program comprised of 3 weekly sessions of 30 minutes of aerobic exercise training for 8 weeks that included running with 50 to 70 percent of maximum heart rate. 48 hours before and 48 hours after the last training session blood samples were collected and serum levels of Myonectine were measured. Analysis of covariance was used to assess differences between groups. Serum levels of Myonectine in the experimental group increased, but not significantly (p=0/08). and insulin resistance significantly decreased in the experimental group compared to the control group (p=0.006). According to the results, that is increase serum levels of myonectin and decrease insulin resistance, on the other hand, concerning myonectin role in increasing fatty acids uptake, exercise training can play important role in decreasing obesity-related diseases and metabolic syndrome that respect to present study, this effect partly related to Myonectin roles.  

References:

منابع

- Abedi, B., Azarbayjani, M.A., Peeri, M., Rasaee, MJ. (2011). The effect of a single session of resistance training on serum adiponectin level and insulin resistance index in sedentary me

منابع

Abedi, B., Azarbayjani, M.A., Peeri, M., Rasaee, MJ. (2011). The effect of a single session of resistance training on serum adiponectin level and insulin resistance index in sedentary men. Arak University of Medical Sciences Journal. 14(5):53-620.

- Blaschke F, Takata Y, Caglayan E, Law RE, Hsueh WA. (2006). Obesity, peroxisome proliferator-activated receptor, and atherosclerosis in type 2 diabetes. Arterioscler Thromb Vasc Biol. 26(1):28-40.

-Boghrabadi,V., Hejazi, SM., Soltani, M., Behnam, VH., Kharazian, S., Soltani, A. (2012).The effect of aerobic exercise on lepin, fasting blood sugar, blood insulin levels and insulin resistant factor in patients with  type 11 diabetes mellitus.

- Després J-P, Lemieux I, Bergeron J, Pibarot P, Mathieu P, Larose E, et al. (2008). Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk. Arterioscler Thromb Vasc Biol. 28(6):1039-49.

- Fox AK, Kaufman AE, Horowitz JF. (2004). Adding fat calories to meals after exercise does not alter glucose tolerance. J Appl Physiol. 97(1):11-6.

- Hadji L, Berger E, Soula H, Vidal H, Géloën A. (2014). White Adipose Tissue Resilience to Insulin Deprivation and Replacement. PloS one. 9(8):e106214.

- Hotamisligil GS. (2005). Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes. Diabetes. 54(suppl 2):S73-S8.

- Kraniou GN, Cameron-Smith D, Hargreaves M. (2006). Acute exercise and GLUT4 expression in human skeletal muscle: influence of exercise intensity. J Appl Physiol. 101(3):934-7.

- Lambers S, Van Laethem C, Van Acker K, Calders P. (2008). Influence of combined exercise training on indices of obesity, diabetes and cardiovascular risk in type 2 diabetes patients. Clin Rehabil. 22(6):483-92.

- Maggio AB, Wacker J, Montecucco F, Galan K, Pelli G, Mach F, et al. (2012). Serum resistin and inflammatory and endothelial activation markers in obese adolescents. J Pediatr. 161(6):1022-7. e1.

- Mann S, Beedie C, Balducci S, Zanuso S, Allgrove J, Bertiato F, et al. (2014). Changes in insulin sensitivity in response to different modalities of exercise: a review of the evidence. Diabetes Metab Res Rev. 30(4):257-68.

- Pessin JE, Saltiel AR. (2000). Signaling pathways in insulin action: molecular targets of insulin resistance. J Clin Invest. 106(2):165.

- Peterson JM, Mart R, Bond CE. (2014). Effect of obesity and exercise on the expression of the novel myokines, Myonectin and Fibronectin type III domain containing 5. PeerJ. 2:e605.

- Raschke S, Eckel J. (2013). Adipo-myokines: two sides of the same coin—mediators of inflammation and mediators of exercise. Mediators Inflamm.

-Sardar MA, Shamsian AA, Taghavi M. (2006). The interaction effect of  glibenclamide and aerobic training on c- peptide, insulin and insulin resistance in type2 diabetic paitients. Iranian Journal of Diabetes and Lipid Disorders. 6(1):91-9.

- Seldin MM, Peterson JM, Byerly MS, Wei Z, Wong GW. (2012). Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis. J Biol Chem. 287(15):11968-80.

- Seldin MM, Lei X, Tan SY, Stanson KP, Wei Z, Wong GW. (2013). Skeletal muscle-derived myonectin activates the mammalian target of rapamycin (mTOR) pathway to suppress autophagy in liver. J Biol Chem. 288(50):36073-82.

-Snowling NJ, Hopkins WG. (2006). Effects of different modes of exercise training on glucose control and risk factors for complications in type 2 diabetic patients a meta-analysis. Diabetes care. 29(11):2518-27.

- Stanson KP, Wei Z, William G, Seldin MM, Lei X, Tan SY. (2013). Skeletal muscle-derived myonectin.

- Tolfrey K, Jones AM, Campbell IG. (2000). The effect of aerobic exercise training on the lipid-lipoprotein profile of children and adolescents. Sports Med. 29(2):99-112.

- Zou C, Shao J. (2008). Role of adipocytokines in obesity-associated insulin resistance. J Nutr Biochem. 19(5):277-86.

 

 

References

Abedi, B., Azarbayjani, M.A., Peeri, M., Rasaee, MJ. (2011). The effect of a single session of resistance training on serum adiponectin level and insulin resistance index in sedentary men. Arak University of Medical Sciences Journal. 14(5):53-620.

- Blaschke F, Takata Y, Caglayan E, Law RE, Hsueh WA. (2006). Obesity, peroxisome proliferator-activated receptor, and atherosclerosis in type 2 diabetes. Arterioscler Thromb Vasc Biol. 26(1):28-40.

-Boghrabadi,V., Hejazi, SM., Soltani, M., Behnam, VH., Kharazian, S., Soltani, A. (2012).The effect of aerobic exercise on lepin, fasting blood sugar, blood insulin levels and insulin resistant factor in patients with  type 11 diabetes mellitus.

- Després J-P, Lemieux I, Bergeron J, Pibarot P, Mathieu P, Larose E, et al. (2008). Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk. Arterioscler Thromb Vasc Biol. 28(6):1039-49.

- Fox AK, Kaufman AE, Horowitz JF. (2004). Adding fat calories to meals after exercise does not alter glucose tolerance. J Appl Physiol. 97(1):11-6.

- Hadji L, Berger E, Soula H, Vidal H, Géloën A. (2014). White Adipose Tissue Resilience to Insulin Deprivation and Replacement. PloS one. 9(8):e106214.

- Hotamisligil GS. (2005). Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes. Diabetes. 54(suppl 2):S73-S8.

- Kraniou GN, Cameron-Smith D, Hargreaves M. (2006). Acute exercise and GLUT4 expression in human skeletal muscle: influence of exercise intensity. J Appl Physiol. 101(3):934-7.

- Lambers S, Van Laethem C, Van Acker K, Calders P. (2008). Influence of combined exercise training on indices of obesity, diabetes and cardiovascular risk in type 2 diabetes patients. Clin Rehabil. 22(6):483-92.

- Maggio AB, Wacker J, Montecucco F, Galan K, Pelli G, Mach F, et al. (2012). Serum resistin and inflammatory and endothelial activation markers in obese adolescents. J Pediatr. 161(6):1022-7. e1.

- Mann S, Beedie C, Balducci S, Zanuso S, Allgrove J, Bertiato F, et al. (2014). Changes in insulin sensitivity in response to different modalities of exercise: a review of the evidence. Diabetes Metab Res Rev. 30(4):257-68.

- Pessin JE, Saltiel AR. (2000). Signaling pathways in insulin action: molecular targets of insulin resistance. J Clin Invest. 106(2):165.

- Peterson JM, Mart R, Bond CE. (2014). Effect of obesity and exercise on the expression of the novel myokines, Myonectin and Fibronectin type III domain containing 5. PeerJ. 2:e605.

- Raschke S, Eckel J. (2013). Adipo-myokines: two sides of the same coin—mediators of inflammation and mediators of exercise. Mediators Inflamm.

-Sardar MA, Shamsian AA, Taghavi M. (2006). The interaction effect of  glibenclamide and aerobic training on c- peptide, insulin and insulin resistance in type2 diabetic paitients. Iranian Journal of Diabetes and Lipid Disorders. 6(1):91-9.

- Seldin MM, Peterson JM, Byerly MS, Wei Z, Wong GW. (2012). Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis. J Biol Chem. 287(15):11968-80.

- Seldin MM, Lei X, Tan SY, Stanson KP, Wei Z, Wong GW. (2013). Skeletal muscle-derived myonectin activates the mammalian target of rapamycin (mTOR) pathway to suppress autophagy in liver. J Biol Chem. 288(50):36073-82.

-Snowling NJ, Hopkins WG. (2006). Effects of different modes of exercise training on glucose control and risk factors for complications in type 2 diabetic patients a meta-analysis. Diabetes care. 29(11):2518-27.

- Stanson KP, Wei Z, William G, Seldin MM, Lei X, Tan SY. (2013). Skeletal muscle-derived myonectin.

- Tolfrey K, Jones AM, Campbell IG. (2000). The effect of aerobic exercise training on the lipid-lipoprotein profile of children and adolescents. Sports Med. 29(2):99-112.

- Zou C, Shao J. (2008). Role of adipocytokines in obesity-associated insulin resistance. J Nutr Biochem. 19(5):277-86.