Effects of l-carnitine on dyslipidemia and anemia in hemodialysis patients

Subject Areas : علوم پزشکی

Mohammad Bagher Najjar Zadeh ¹ , Maedeh Sadeghi Naeini pour ² , Mahmud reza Khazaei ³

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Received: 2017-06-06 Accepted : 2017-06-06 Published : 2012-11-21

Keywords: L-Carnitin, dyslipidemia, Anemia, hemodialys, chronic RenalFailure (CRF),

Abstract :

Introduction In patients on maintenance hemodialysis several factors reduce the body stored carnitine which could lead to dyslipidemia and anemia in these patients. We evaluated the effect of oral L-carnitine supplementation on lipid profiles and anemia in hemodialysis patients. Methods and Materials Thisrandomized clinical trialwas performedon patients undergoing continuous hemodialysis. Of 63 hemodialysis patientswere studied, 30 patients inthe control groupand 33 casesres pectively. The case group were treated for 6 months with oral L-carnitine (250 mg threetimes daily). At the beginning andthe end of thestudy, hemoglobin, triglycerides, total cholesterol, LDL, HDL, VLDL, albumin, KT / v, height, weight, BMI was measured. And withthe Demographic characteristics questionnaires were collected. Data collected by the spssv20 software  and other Statistical Methods descriptive and analytical  were evaluated. Results  There was no  significant changes in hemoglobin levels between the two groups. Compared between the 2 groups in terms of changes in lipid profile seems this medicine is not very effective in modifying lipid profiles, although slight and positive changes in lipid profile in Group (cases)  were found. The drugcauseda significant reductioninbody weight.And the mean BMI was significantly reduced in the cases group than the control group. Significant differences between the two groups in terms of changes in albumin is not found . Conclusion It seems to correct anemia and hyperlipidemia medication use carnitine is not effective in hemodialysis patients. However, use of this medication is effective in reducing the patient's weight loss and BMI.    

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