مقایسه اثر لیدوکائین و آتراکوریوم بر فاسیکولاسیون ناشی از سوکسینیل کولین در اعمال جراحی تحت بیهوشی
Subject Areas : علوم پزشکیMojgan Raisi 1 , Sara Abutalebi Nasr Abad 2
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Keywords: Atracurium- Lidacaine- Fasciculation,
Abstract :
Background & Aim: Succinylcholine has obvious advantages for facilitating endotracheal intubation in the ambulatory setting patients (eg:low cost, fast onset and no need for reversal of neuromuscular relaxant). Unfortunately postoperative myalgia and fasciculation may frequently occur after the use of succinylcholine and these side effects may be particularly troublesome in outpatients. This study was conducted to evaluate the efficacy of Atracurium or lidocaine alone or together on succinylcholine induced fasciculation in general anesthesia surgeries. Patients and methods: This study was conducted on 90 ASA physical status I, II patients that were scheduled for general anesthesia surgeries. Patients were randomly assigned to one of the two groups (n=45 for each group); group 1: 0.05 mg/kg atracirium (5cc) 3 minurtes before anesthesia induction, group 2: 1/5 mg/kg lidocaine (5cc) 20 seconds before anesthesia induction was administered. During induction of anesthesia incidence of facciculation was assessed and four point rating scale was used for its severity assessment. For each of patients data collected included demographic variables (eg: age, sex, duration of operation), presence or absence of fasciculation, severity of fasciculation. Differences analyzed via Fisher's Exact test and Chi- square test. P value <0.05 was considered significant. Results: Mean age of patients was 34.72±11.56 (33.69±11.45 in Lidocaine and 35.96± 11.69 in Atracurium groups) years, 53.3% of them were women, there was no significant differences between two groups considering age and Sex. In Lidocaine group points Zero, one two and three belonyed to 51.1% , 24.2%, 15.6% and 8.9% respectively, similarly for Atracurium group 64.4% , 17.8%, 11.1% and 6.7% respectively . incidence and severity of fasciculation showed no significant differences between two groups (p>0.05). Efficacy of each Lidocaine or atracurium on fasciculation was similar in both sexes and in all age groups (p>0.05) Cunclusion: Although atracurium was more effective in preventing fasciculation due to succiniycholine, but the difference was not significant.