بررسی عملکرد سیستو لیک بطن چپ به وسیله اکو کاردیو گرافی بافتی در کودکان مبتلا به سندرم داون
Subject Areas : علوم پزشکی
Saeid
Abtahi
1
()
Maryam
Rafiei Torghabe
2
()
Keywords: down syndrome- Echocardiographic Doppler Tissue (TDI)-Down syndrom,
Abstract :
Evaluation of lv systolic function by Doppler tissue echocardiography in children with Down syndrom Background: Tissue Doppler imaging (TDI) is a relatively new echocardiographic method that was first described and clinically applied by Isaaz from France in the 1980’s. This modality is evaluating ventricular function in both the systolic and the diastolic assessment. Information about the TDI is very low. The aims of this study was to determine the cardiac functions in Down syndrome children who did not have structural cardiac lesion by conventional and tissue Doppler echocardiography. Materials and Methods: In this study, a group of 36 children with Down syndrome,between 4 month and 19 years of age without anatomic heart disease were subjected to the assessment both ventricular systolic function by both two-dimensional and tissue Doppler echocardiography. Velocity of S, A', E ', A and E at the level of the mitral and tricuspid valves, and septum were measured.As well as other data such as FS, HR and EF were measured. All the above data into statistical software was SPSS ver.21 were analyzed. Result: In this study wave velocity was not associated with children sex.but there was associated Between children age and Awave of treicuspid .A wave velocity of tricuspid raised when body surface area decread. EF and FS were nat associated with body surface area-sex and age .there were associated between body surface area and E´waves of septum.velocities of E´wave of septum raised when body surface area raised. In this study, an average of the Heart wall motion at the level of the mitral valve based on S wave was calculated0.07 ± 0.01cm/s, Based on E´ wave:0.12 ±0.03 cm/s, Based on A´ wave:0.07 ±0.03 cm/s , Based on E wave: 1.15±0.15cm/s and Based on A wave:0.74 ±0.2 cm/s. An average of the Heart wall motion at the level of tricuspid valve based on S wave was calculated0.11±0.02 cm/s, Based on E´ wave:0.15 ±0.04 cm/s, based on A´ wave:0.1 ±0.04cm/s,Based on E wave:0.82 ±0.19 cm/s and Based on A wave:0.63 ±0.19 cm/s .An average of the Heart wall motion at the level of septum based on S wave was calculated 0.07±0.1 cm/s, Based on E´ wave: 0.11±0.02 cm/s and based on A´ wave: 0.06±0.02 cm/s. Conclusion: Despite having an apparently normal heart, children with Down syndrome may have silent disturbed cardiac functions, which may be discovered by twodimensional or tissue Doppler echocardiography.
1)Shariati M. Genetic epidemiology of Down syndrome in Iran. ISMJ. 2005; 7 (2) :122-127.
2)Smith M,Visootsak J. Noninvasive screening tools for Down syndrome:2013 Mar 6;5:125-31.
3)Charlotte A.Hobbs, Stephanie L. Sherman, PING Y. Polymorphisms in Genes Involved in Folate Metabolism as Maternal Risk Factors for Down Syndrome.,2000 September;67(3):623-630.
4)نلسون .دانیال برشتین. بیماری های کودکان.ج 3: بیماری های قلب کودکان. ترجمه دکتر ناصر بینافر.تهران:1389صفحه 170-150
5)Mark Selikowitz,Clemmons RD, Down syndrome 2008 Sep;14:34-39.
6)Dashe O,Barbara L,Hoffman ND,.prenatal Diagnosis and fetal therapy.in:F.Gary Cunningham,Kenneth J,Levena ,Steven L,Bloom,John C.Williams obstetrics,23rd ed. 2010;292-297.
7)Wu J,Morris Jk. Trends in maternal age distribution and the live birth prevalence of Down's syndrome in England and Wales: 1938-2010 . 2013 Jan 30.
8)Stephanie L.Sherman,Emily G.Allen, Lora H.Bean,Sallie B.Freeman.2007 OCT;3:221-227.
9)Hook ,Ernest B .MD Rates of Chromosome Abnormalities at Different Maternal Ages 1981 september;58:3-6.
10) Hollis ND,Allen EG,Olliver TR,Tinker SW. Preconception folic acid supplementation and risk for chromosome 21 nondisjunction: a report from the National Down Syndrome Project 2013 Mar;161(3)438-44.
11) Eskes TK. Abnormal folate metabolism in mothers with Down syndrome offspring 2006 Feb 1;124(2):130-3.
12) AH Bittles, E J Glasso.Clinical, social, and ethical implications of changing life expectancy in Down syndrome 2007 Feb 64;4:282-286.
13) K.E.Wisniewski M.D. Down syndrome children often have brain with maturation delay, retardation of growth, and cortical dysgenesis 2005 Jun 37;57:274-281.
14) Siegfried M.Pueschel M.D.Clinical aspects of down syndrome from infancy to adulthood 2005 Jun3;57:52-56.
15)Charlotte Ference.Catherine A.Neill,Joann A.Boughman,Judith D.Rubin, Congenital cardiovascular malformations associated with chromosome abnormalities: An epidemiologic study,1989 janeuary ;114(1):79-86.
16) Elmaqrpy Z,Rayani A,Shah A,Habas E,Aburawi EH. Down syndrome and congenital heart disease: why the regional difference as observed in the Libyan experience?2011 NOV-Dec;22(6):306-9.
17) Barlow GM , chen XN , shi ZY , lyons GE, Down syndrome congenital heart disease: a narrowed region and a candidate gene.2001 Mar –Apr;3(2):91-101.
18)Lee Goldman md, Dennis Ausiello md,. Diagnosis of heart disease .in;William p .Arend,Robert c,Griggs,James O,Nicholas Larusso, David R.Andreoli and Carpenter Cecil essentials of medicine, 8thed.2010;328-341.
19) Arthur Garson JR, Bricker JT, Fisher DJ, et al. The science and practice of
pediatric cardiology. 2nd edition, Philadelphia: William and wilkins; 1998. p.
128-53.
20) Moler JH, Hoffman JE. pediatric cardiovascular medicine. 1th edition. Philadelphia: Chuerchil livingstone;2002.p60-151.
21) Anderson RH, Baker EJ, Mac carty FJ, et al.Pediatric cardiology. 2nd edition.
London: Chuerchil livingstone; 2002.456-565.
22)Patrick T.O Gara, Loscalzo JO. Diagnosis of cardiovascular Disorder. In: Anthony S,Eauci,Dennis L,Kasper,Dan L,Longo ,Joseph Loscalzo,Stwphen L.Harrison’s principles of internal medicine, 18th ed,2012.1821-1830.
23) Biley JJ, Berson AS, Garson A Jr, et al. Recommendations for standardization
of leads and of specifications for instruments in electrocardiography and
vector cardiography: report of the Committee on Electrocardiography and Cardiac Electrophysiology of the Council on Clinical Cardiology. American Heart
Association Circulation 1990;81:730-739.
24) Zamorano J, Wallbridge D, Drozd J,Nesser J,Erbel R. J. Non-invasive assessment of cardiac physiology by Tissue Doppler echocardiography,Eurheart J.1997 Dec;18:330-339.
25) Budinger TF, Berson A, McVeigh ER, et al. Cardiac MR imaging: report of
a working group sponsored by the National Heart, Lung and Blood Institute..1998;208:573-576.
26) Skandar S,Skanderian A.Risk assessment using single photon emission comuted tomographic thecnetium -99m sestamibi imaging.Am Coll cardiol.1998;32:57-62.
27) Kenneth Kerut E, Mcllwai EF, Plotnick G. Handbook of Echo-Doppler Interpretation. 2nd ed. New York; 2004;54-60.
28) Andrew M.Tissue Doppler Echocardigraphy.Society Of Cardiovascular
Anesthesiologists.2010;130-135.
29) Kapusta L. Echocardiographicassessment of anthracycline cardiotoxicity in
children. 2nd edition. Israel: Nigimegen University Press;1957;2:120-128.
30) Kimbalt T,Mechelfelder E.Echocardiography :Allen, allex,Hughd,Driscoll,shaddy D,Robbertero E,Timothy F.Moss and Adem.Heart disease in infants children and adulsensce including the fetus and young adult 7th edition. Lippinett Williams wilkinsp.2008;156-157 and539-561.
31) Baruch C, Gradaus R, Gunia S, Breithardt G, Wichter T. Doppler tissue
analysis of mitral annular velocities: Evidence for systolic abnormalities in patients with diastolic heart failure. J Am Soc Echocardigraphy.2003;16;1031-1036.
32) Pellerin D,Sharma R,Elliott P,Veyrat C.Tissue Doppler,strain,and strain rate echocardiography for the assesmant of left and right systolic ventricular function.British Medical Association.2003 NOV;89(3):9-17.
33) kapusta L.The current knowledge of the tissue Doppler imaging technique.In:
kapusta L. tissue doppler imaging: Echocardiographic assessment of
anthracyclins cardiotoxicity in children. Israel: Nijmegen university Press.2002;P.27-40.
34) Donovan CL, Armstrong WF, Bach DS. Quantitative Doppler tissue imaging
of the left ventricular myocardium: validation in normal subjects. Am earth.1995;20:100-104.
35) Poulsen SH, Andersen NH, Ivarsen PI, Mogensen C-E, Egeblad H. Doppler
tissue imaging reveals systolic dysfunction in patients with hypertension and apparent "isolated' diastolic dysfunction. J Am Soc Echocardiogr .2003;16:724-731.
36) Negrin RJS,Chikermane A,Wright JGC,et al. Assesment of miyocardial
function in neonates using tissue Doppler imaging. Arch Dis Child Fetal Neonatal
oct 30.2010;304-306.
37) Fleming AD, McDicken WN, Sutherland GR, Hoskins PR. Assessment of
colour Doppler tissue imaging using test-phantoms. Ultrasound Med Biol.1994;20:937-951.
38) Zamorano J, Wallbridge D, Drozd J,Nesser J,Erbel R. J. Non-invasive assessment of cardiac physiology by Tissue Doppler echocardiography,Eurheart European Heart Journal.2010 December;18:330-339.
39) Hunter L,Pate N.Echocardiography and the neonatologist.J Paediatr Child Health 2010 Apr;21(6):254-258.
40) Al- Biltagi M, Serag AR ,Hefidah MM, Mabrouk MM.Cardiol YouNG. Evaluation of cardiac functions with Doppler echocardiography in children with Down syndrome and anatomically normal heart 2012 Apr 26:1-7.
41) E Toscano, G Pacileo, G Limongelli, M Verrengia, O Di Mita, Subclinical hypothyroidism and Down’s syndrome; studies on myocardial structure and function.Arch Dis Child 2003;88:1005-1008.
42) Maria Giovanna Russo , MD , Giuseppe Pacileo , MD , Bruno Marino , MD, Carlo Pisacane , MD ,Echocardiographic Evaluation Of Left Venticular Systolic Function in the Down Syndrom.the American Journal of cardiology 1998 May 15.81:30-35.
43) Joseph Seward, Rick A, Raymond J, Heart disease in persons with Down Syndrom,1998 Nov;16:185-203.
44)Doff B. Mcelhinney.Michele StraKa.Elizabeth Goldmuntz.Elaine H.ZacKai.Correlation between abnormal cardiac physical examination and echocardiographic findings in neonates with Down syndrome.2002 Apr;113:3:238-241.
45) Cui W, Roberson DA, Chen Z, Madronero LF, Cuneo B. Systolic and diastolic
time intervals measured from Doppler tissue imaging: normal values and
Z-score tables, and effects of age, heart rate, and body surface area. J Am Soc Echocardiogr.2008 Apr;21(4):361-370.
_||_
