بررسی تاثیر قطره ی چشمی فلورومتولون بر میزان ایجاد عارضه فشار داخل چشم بعد از عمل PRK

Subject Areas : علوم پزشکی

Ladan Safarian Toosi ¹ , Hamid Khakshor ² , Mohammad reza Vojdani ³

1 - استادیار، دانشکده پزشکی، دانشگاه آزاد اسلامی مشهد، مشهد، ایران.
2 - استادیار، دانشکده پزشکی، دانشگاه آزاد اسلامی مشهد، مشهد، ایران.
3 - دانشجوی رشته پزشکی، دانشکده پزشکی، دانشگاه ازاد اسلامی مشهد، مشهد، ایران.

Received: 2017-06-06 Accepted : 2017-06-06 Published : 2012-05-21

Keywords: Intraoccular pressure–Flurometholone-Photorefractive keratectomy,

Abstract :

Background and objective: Photorefractive keratectomy (PRK) is generally believed to be safe and effective for treatment of myopia. Steroid responders may develop elevated intraocular pressure (IOP) within a short time following steroid administration. This ocular hypertensive response to corticosteroids is an autosomal dominant trait found in one third of the general population. The current study was performed to evaluate the incidence of Flurometholone induced ocular hypertension following myopic PRK. Methods: PRK was performed on 400 eyes of 200 patients. Flurometholone was administered for first group %0.1 four times a day in first week each time one drop, 3 times a day for second week, 2 times for third week and one time a day for forth week. Second group received FML %0.1 for 3 months, first months 4 times, second month 3 times and third month 2 times a day each time one drop, Intraocular pressure (IOP) was measured preoperatively, after 1, 2 and 3 month(s) in both groups. Data was statistically analyzed using SPSS V21. Results: Mean age of first and second groups were 30.2± 5.58 and 30.2± 5.68 years respectively. 74 percent of first and 73% of second group were women. Mean IOP of right eyes preoperatively, after 1, 2 and 3 months were 15.1± 2.13, 15.5± 2.06 , 16.2±1.81 and 17.2±2.06 mmHg in group 1 respectively, and in group 2 , 15.4±2.04 , 15.8±1.98, 16.2±2.07 and 17.2± 2.08 mmHg respectively. IOP of left eyes in group 1 were 15.1±2.03, 15.5±1.98, 16.4±1.87 and 17.2±1.77 mmHg and in group 2 15.4±2.03, 15.9±1.95, 16.4±1.96 and 17.5±1.75 mmHg respectively. There was no difference between two groups considering IOP and also in details (men and women, 20-35 and 36-50 years) no significant differences was seen between two groups considering IOP in each time level (P>0.05). Conclusion: In this cohort, reducing regimens of FML proved to be a safe anti- inflammatory treatment in terms of avoiding corneal haze after PRK.  

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