Association between restless legs syndrome and primary headache in patient referred to neurology clinic of 22Bahman Hospital,Mashhad,2012-2013

Subject Areas : علوم پزشکی

Mohsen Mahdi Nejad Kashani ¹ , Fatemeh Rahimi ²

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Received: 2017-06-06 Accepted : 2017-06-06 Published : 2012-11-21

Keywords: Primary headache- Restless legs syndrome- Sleep disorder,

Abstract :

Background and Objective: A large series of clinical and experimental observations on the interactions between migraine and the extrapyramidal system are available. The aim of this study was to evaluate assosiation between restless leg syndrome (RLS) and primary headache in patient referred to neurology clinic. Methods: patients referred to clinic of neurology of 22Bahman hospital were evaluated for primary headaches according to HIS cirteria. Then patients with other neurologic disorders which caysed to RLS were excluded. Patient with primary headache only were interviewed for RLS according to international criteria and if affected, its frequency in week and sleep disorders were evaluated. Then a family member of patient without headache was reviewedfor RLS. Data was reviewed for RLS. Data was statistically analyzed using SPSS software. Results: There were 100 patients with primary headaches and 100 without headache as control group evaluated. 67% of case group and 64% of control were women. Mean age of case and control groups were 35.4±12.1 and 35±12.3 years respectively. There were 68% migrain, 29% tension and 3% were cluster headaches. There was a significant relaton between primary headaches and RLS (32% in case group and 12% in control group were affected). In patients with headache pluse RLS, sleep disorder was seen in 75% . 34.6% of men with headache had RLS (p=0/008) and 29.9% of women with headache had RLS (P=0.022). Frequency of RLS in patients with headache increased as age increased (p<0.05). Conclusion: As RLS is significantly higher in headache patients more studies are needed in order to find same pathogenic ways.  

References:

 

1-      Biary N, Koller W, Langenberg P. Correlation between essential tremor and migraine headache. J Neurol Neurosurg Psychiatry.1990; 53(11):1060–1062.

2-      Kwak C, Vuong KD, Jankovic J. Migraine headache in patients with Tourette syndrome. Arch Neurol. 2003; 60(14):1595–1598.

3-      Teixera AL Jr, Meira FC, Maia DP, et al. Migraine headache in patients with Sydenham’s chorea. Cephalalgia. 2004; 25(5):542–544.

4-      Rains JC, Poceta JS. Headache and sleep disorders: review and clinical implications for headache management. Headache. 2006; 46(11):1344–1363.

5-  Bigal ME, Lipton RB. Headache Classification. In: Bigal ME, Lipton RB. Migraine and other headache disorders. 1^st ed.New York: Informa; 2006. P.1-21.

6-      Michael J. Aminoff, David A, Roger P. Chronic headache clinical neurology. NewYork. Lange medical book S/MC Graw Hill; 2005.p. 85-91.

7-      Evans RW, Mathew NT.Hand book of headache. 12^th ed. Philadelphia :lipincotte Williams & Wilkins; 2001.p.350-339.

8-      Davidoff RA. Migraine manifestations, pathogenesis, and management.2^nd ed. New York: Oxford university press; 2002.p. 3-89.

9-      Cheung RT, Prevalence of Migraine, Tension-type headache , and other headaches in Hong Kong. Headache. 2000 Jun; 40(6):p473-9.

10- Bradley WG, Daroff RB, Fenichel GM, Jankovic J, editors. Neurology in clinical practice. 5th edition. Philadelphia: Elsevier’s Health Sciences Rights Department. 2008;p:2011–62.

11- Low NC, Merikangas KR. Comorbidity of migraine. In: Bigal ME, Lipton RB. Migraine and other headache disorders. 1^st ed. New York: Informa; 2006. P.45-60.

12. Ekbom KA. Restless legs. Acta Med Scand Suppl. 1945; 158(1):1-123.

13.Montplaisir J, Nicolas A, Godbout R, Walters A. Restless Legs Syndrome and Periodic Limb Movement Disorders. In: Kryger M, Roth T, Dement W. Principles and practice of Sleep Medicine. 3^rd ed. Philadelphia: saunders company; 2000. 742-752.

14. Montplaisir J, Boucher S, Poirier G, et al. Clinical poly somnographic and genetic characteristics of restless legs syndrome: a study of 133 patients diagnosed with new standard criteria. Mov Disord. 1996; 12:61-65.

15. Trenkwalder C, Walters AS, Hening W. Periodic limb movements and restless legs syndrome. Neural Clin. 1996; 14:629-649.

16. Coleman RM, Bliwise DL, Sajben N, et al. Epidemiology of peridic movements during sleep. In: Guilleminault C, Lugaresi E, eds. Sleep/ Wake Disorders. Natural History, Epidemiology and Long Term Evolution. New York, NY: Raven Press; 1988: 217-229.

17. The International Restless Legs Syndrome Study Group. Towards a better definition of the restless legs syndrome from the international restless legs syndrome study group. Mov Disord. 1995; 10:634-642.

18. Ondo W, Jankovic J. Restles legs syndrome: clinicoetiologic correlates. Neurology. 1996; 47: 1435-1441.

19. Rutkove SB, Matheson JK, Logigian EL. Restless legs syndrome in patients with polyneuropathy. Muscle Nerve. 1996, 19:670-672.

20. Matthew WB. Iron deficiency and restless legs. Br Med J. 1976; 1:898.

21. Yunus MB, Aldag JC. Restless legs syndrome and leg cramps in fibromyalgia syndrome: a controlled study. Br Med J. 1996; 312: 1339.

22. Reynolds G, Black DR, Pall HS, et al. Restless legs syndrome and rheumatoid arthritis. Br Med J. 1986; 292: 659-660.

23. d’Onofrio, D. Cologno, V. Petretta, et al. Restless legs syndrome is not associated with migraine with aura: a clinical study. Neurol Sci 2011; 32: 153–156.

24. Chen PK, Fuh JL, Chen SP, Wang SJ. Association between restless legs syndrome and migraine.J Neurol Neurosurg Psychiatry 2010; 81(5):524-8.

25.Florindo d’Onofrio, Gennaro Bussone, Daniela Cologno, et al. Restless legs syndrome and primary headaches: a clinical study. Neurol Sci 2008; 29: 169–172.

26. Fernández-Matarrubia M¹, Cuadrado ML, Sánchez-Barros CM, Martínez-Orozco FJ, Fernández-Pérez C, Villalibre I, Ramírez-Nicolás B,Porta-Etessam J. Prevalence of Migraine in Patients With Restless Legs Syndrome: A Case-Control Study. Headache. 2014 May 20;43(5):567-573.

27. Zanigni S¹, Giannini G, Melotti R, Pattaro C, Provini F, Cevoli S, Facheris MF, Cortelli P, Pramstaller PP. Association between restless legs syndrome and migraine: a population-based study. Eur J Neurol. 2014 May 20;15(3):326-332.

28. Gozubatik-Celik G1, Benbir G, Tan F, Karadeniz D, Goksan B. The prevalence of migraine in restless legs syndrome. Headache. 2014 May; 54(5):872-7.

29. Seidel S1, Böck A, Schlegel W, Kilic A, Wagner G, Gelbmann G, Hübenthal A, Kanbur I, Natriashvili S, Karwautz A, Wöber C, Wöber-Bingöl C. Increased RLS prevalence in children and adolescents with migraine: a case-control study. Cephalalgia. 2012 Jul;32(9):693-9.

30. Gupta R¹, Lahan V, Goel D.  Primary headaches in restless legs syndrome patients. Ann Indian Acad Neurol. 2012 Aug;15(Suppl 1):S104-8.

31. Florindo D¹, Daniela C, Giulio C, Vittorio P, Gabriella M, Vincenzo T, Eliana M, Gerardo C, Gennaro B.  Cluster headache patients are not affected by restless legs syndrome: an observational study. Clin Neurol Neurosurg. 2012 May;113(4):308-10.

32. Rhode AM¹, Hösing VG, Happe S, Biehl K, Young P, Evers S. Comorbidity of migraine and restless legs syndrome--a case-control study. Cephalalgia. 2009 Nov;27(11):1255-60.