Inflammation Reduction by Acacetin Caused by Renal Ischemia-Reperfusion in Rats

Subject Areas : Journal of Animal Biology

Alvand Alwani ¹ , Abdul Hossein Shiravi ² , Ali Ghanbari ³ , Gholamhassan Vaezi ⁴ , Siros Jalili ⁵

1 - Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran.
2 - Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran.
3 - Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
4 - Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran.
5 - Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

Received: 2021-04-26 Accepted : 2021-08-28 Published : 2022-11-22

Keywords: Inflammation, kidney, ischemia/reperfusion, Acacetin,

Abstract :

Ischemia/reperfusion occurs for a number of reasons; the most important of all is the closure of the renal arteries during renal transplantation. Inflammation is one of the most important mechanisms that occurs during ischemia / renal perfusion. Acacetin is a natural flavonoid with many healing properties. This study has investigated the effect of Acacetin ischemia / renal reperfusion inflammation on mice. 84 male balb/ c mice were randomly divided into 12 groups (each group consisted of 7 heads). Groups included control, sham, ischemia, casting control, casting sham, and ischemia/reperfusion. Ischemia was performed by closing the left renal artery for 60 minutes. Acacetin groups received this substance in 10, 25, and 50 doses mg/kg intraperitoneally. Kidney tissue hobby samples were used to measure cytokines including alpha necrosis factor, interleukin 1 beta, and toll like receptor 4 as well as myeloperoxidase. The levels of serum ions prepared from the cardiac blood of rats were evaluated. The levels of inflammatory cytokines in the ischemia/reperfusion group were significantly increased (p <001). While these variables did not show significant changes in the groups receiving Acacetin. Myeloperoxidase levels were significantly increased in ischemia/reperfusion groups (p <001). While these variables did not show significant changes in the groups receiving Acacetin,

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