Inflammation Reduction by Acacetin Caused by Renal Ischemia-Reperfusion in Rats
Subject Areas : Journal of Animal Biology
Alvand Alwani
1
(
Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran.
)
Abdul Hossein Shiravi
2
(
Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran.
)
Ali Ghanbari
3
(
Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
)
Gholamhassan Vaezi
4
(
Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran.
)
Siros Jalili
5
(
Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
)
Keywords: Inflammation, kidney, ischemia/reperfusion, Acacetin,
Abstract :
Ischemia/reperfusion occurs for a number of reasons; the most important of all is the closure of the renal arteries during renal transplantation. Inflammation is one of the most important mechanisms that occurs during ischemia / renal perfusion. Acacetin is a natural flavonoid with many healing properties. This study has investigated the effect of Acacetin ischemia / renal reperfusion inflammation on mice. 84 male balb/ c mice were randomly divided into 12 groups (each group consisted of 7 heads). Groups included control, sham, ischemia, casting control, casting sham, and ischemia/reperfusion. Ischemia was performed by closing the left renal artery for 60 minutes. Acacetin groups received this substance in 10, 25, and 50 doses mg/kg intraperitoneally. Kidney tissue hobby samples were used to measure cytokines including alpha necrosis factor, interleukin 1 beta, and toll like receptor 4 as well as myeloperoxidase. The levels of serum ions prepared from the cardiac blood of rats were evaluated. The levels of inflammatory cytokines in the ischemia/reperfusion group were significantly increased (p <001). While these variables did not show significant changes in the groups receiving Acacetin. Myeloperoxidase levels were significantly increased in ischemia/reperfusion groups (p <001). While these variables did not show significant changes in the groups receiving Acacetin,
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