The Effect of Shirazi Thyme (Zataria multiflora) Consumption During Pregnancy on Neonatal Physical Growth in Wistar Rats

Subject Areas : Journal of Animal Biology

Khatereh Safavi Naeine ¹ , Zahra Shojaei Ardekani ²

1 - Department of Midwifery, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran
2 - Department of Midwifery, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran

Received: 2020-04-21 Accepted : 2020-10-18 Published : 2021-05-22

Keywords: pregnancy, Rat, Zataria multiflora, neonate, Physical growth,

Abstract :

Zataria multiflora (Shirazi Thyme) is one of the plants which has become popular due to its suitable compounds. Pregnancy is a high-risk period in which the consumption of substances which affect the physical growth of neonate can cause the disorders. This study was performed on 32 female Wister rats weighing 210 ± 10 g who were randomly divided into 4 equal groups. Zataria multiflora extract was prepared by the distillation, and different concentrations (400, 800, 1000 mg/kg/day) which were administered by gavage during the pregnancy. The control group only received normal food and water. After the birth, the weight, height, and head circumference of neonate’s rat was measured on the first, third, and fifth days of birth. Findings were analyzed by SPSS software using one-way analysis of variance. The results showed a significant decrease in the circumferential changes in the neonates of study groups. No significant difference was observed in the weight changes. The consumption of Shirazi thyme during pregnancy reduces the height and head circumference in neonate’s rats; hence, it should be cautiously used.

References:

1. Ahmed M.,  Hwang J.H.,  Choi

^,S., Han D. 2017. Safety classification of herbal medicines used among pregnant women in Asian countries: a systematic review. BMC Complementary Alternative Medicine, 17: 489-498.

2. Anvari M., Dashti M.H., Zeinali F., Beyoki S.M.H. 2011. Evaluation of the effect of Shirazi thyme infusion on the condition of placenta and embryos of rat mice. Journal Medicinal plants, 38 (2):19-25. [In Persian].

3. Boskabady M.H., Gholami Mohtaj L. 2014. Effect of the Zataria multiflora on systemic inflammation of experimental animal’s model of COPD. BioMedical Research. International,11(2):1-9.

 4. Hamta A., Ghazaghi S. 2014. The study of Thymus vulgaris Cytotoxicity effects on breast cancer cell's line. Journal of Sabzevar University of Medical Sciences, 21(1): 122-130.

5. Hotta M., Nakata R., Katsukawa M., Hori K., Takahashi S., Inoue H. 2010. Carvacrol, a component of thyme oil, activates PPAR alpha and gamma and suppresses COX-2 expression. Journal of Lipid Research, 51(1): 132-9.

6. Kennedy D. A,  Lupattelli A,  Koren G, and  Nordeng H. 2016. Safety classification of herbal medicines used in pregnancy in a multinational study. BMC Complementary Alternative Medicine, 16: 1-9.

7. Prabu P.C., Panchapakesan S. 2015. Prenatal developmental toxicity evaluation of Withania somnifera root extract in Wistar rats. Journal Drug and Chemical Toxicology,  38(1): 50-56.

8. Pretorius E., Marx J. 2006. Datura stramonium in asthma treatment and possible effects on prenatal development.  Environmental Toxicology and Pharmacology,  21(3): 331-337.

 9. Rayburn W.F., Gonzalez G.L., Christensen H.D., Stwart J.D .2011. Effect of prenatally administered hypericum (St John’s wort) on growth and physical maturation of mouse offspring. American Journal of Obstetrics and Gynecology, 184(2): 191-195.

10. Raoufi-nejad K., Javadi M., Torkamandi H., Rajabi1 M., Moeini A., Khanavi M., Gholami K. 2012. Adverse drug reactions of herbal medicines during pregnancy amongst Iranian women. Research in Pharmaceutical Sciences, 7(5): 980-993. [In Persian].

11.  Yimam M.,  Lee Y.C.,  Hyun E.J.,  Jia Q. 2015.  Reproductive and Developmental Toxicity of Orally Administered Botanical Composition, UP446‐Part II: Effects on Prenatal and Postnatal Development, Including Maternal Function in Sprague–Dawley Rats. Birth Defects Research Part B: Developmental and Reproductive Toxicology, 104(4): 166-176. 

12. Zin S.R., Kassim N.M., Mohamed Z. ,Fateh A.H., Alshawsh M.A. 2019. Potential toxicity effects of Anastatica hierochuntica aqueous extract on prenatal development of Sprague-Dawley rats. Journal of Ethnopharmacology, 245:1-9.

13. Zu Y., Yu H., Liang L., Fu Y., Efferth T., Liu X. 2010. Activities of ten essential oils towards Propionic bacterium acnes and PC-3, A-549 and MCF-7 cancer cells. Molecules, 15(5): 3200-3210.