Effect of Palmatyn Hydrochloride on Some of Serum Biochemical Parameters in Streptozotocin-induced Diabetic Rats ر

Subject Areas : Journal of Animal Biology

پیراسته نوروزی ¹ , حمید کلالیان مقدم ² , ویدا حجتی ³

1 - گروه زیست شناسی، واحد دامغان، دانشگاه آزاد اسلامی، دامغان، ایران
2 - گروه فیزیولوژی، دانشگاه علوم پزشکی شاهرود، شاهرود، ایران
3 - گروه زیست شناسی، واحد دامغان، دانشگاه آزاد اسلامی، دامغان، ایران

Received: 2015-01-27 Accepted : 2017-05-21 Published : 2015-01-21

Keywords: Cholesterol, Rats, Diabetic, Palmatine, Glucose. ر,

Abstract :

Diabetesis a metabolic disorder that gripped mankind since time immemorial has been the world's top. Oxidative stress is the result of diabetes and its complications in a large amount of communication. Antioxidants, especially of plant origin are very important in the prevention of diabetes complications.The aim of this study was to evaluate the effect on the Hydrochloride Palmatyn biochemical parameters in streptozotocin-induced diabetic rats is. In this study, 32 male Wistar rats weighing approximately 240 g, were randomly selected and divided into four groups: contro l, non-diabetic Palmatine treated, diabetic and hydrochloride Palmatine diabetic.Intraperitoneal injection of 55 mg/kg streptozotocin diabetes was induced.One week after injection, treated with hydrochloride Palmatine 10mg/kg/Day dose for six weeks and injections were performed. Testicular damage by hematoxylin - eosin specified Vfaktvrhay Vhvrmvny biochemical blood was measured.Data Software prism-5.0-test were analyzed by one way ANOVA and Tukey.The results show that diabetes induced oxidative stress and production of free radicals increase glucose and reducing the secretion in blood insulin, cholesterol and triglyceride abnormalities are disorder.Palmatynin samples treated with these complications improved, the levels of glucose, cholesterol, triglycerides decreased P ≤ 0.001)) Outer hyperinsulinemia (P ≤ 0.001) is. Considering the obtained results, it was found that Palmatine hydrochloride low creators effect on blood glucose and lipid in diabetic rats, the effect can be to reduce the effects of cardio - vascular disease caused by diabetes mellitus be considered. ر