The Effect of Anethum graveolensExtract on Changes of Estrogen and Progesterone Hormones in treatment of Polycystic Ovary in Rats
Subject Areas : Journal of Animal Biology
وحید
حمایت خواه جهرمی
1
(گروه زیست شناسی، واحد جهرم، دانشگاه آزاداسلامی، جهرم، ایران)
پریسا
زارعی فردجهرمی
2
(گروه زیست شناسی، واحد جهرم، دانشگاه آزاداسلامی، جهرم، ایران)
Keywords: estrogen, progesterone, Rat, Anethum graveolens, Polycystic,
Abstract :
One of the most common causes of in fertility is polycystic ovary syndrome (PCOS) and 6-8 percent of womens of child bearing age are affected with endocrine disorders. If the extract contains flavonoids, phytoestrogens are compounds that are effective in treating many diseases. The purpose of this study was to investigate the effect of changes in estrogen and progesterone hormones in polycystic mice.35 female Wistar rats weighing 20±180g in 2 to 3 consecutive estrous cycles were selected. Then divided into 5 groups of 7 to include a control group (no drug), polycystic group (day 4 mg/kg estradiolvalerate drugs were given intramuscularly), experimental 1, 2 and 3 groups, which also received 4mg/kg estradiolvalerate medication, daily doses, minimum, average and maximum to extract the received intraperitoneally. After 21days, all mice were bled to measure the hormones estrogen and progesterone was used.Level estrogen concentrations in the polycystic group and the experimental group that Anethum graveolens minimum and average dose received has increased significantly compared with control requirements. Progesterone concentration in polycystic experimental group has a significant decrease compared with control requirements. The subjects were identified that are likely to extract improves ovary polycystic syndrome due to changes in the concenteration of estrogen and progesterone hormones.
