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Manuscript ID : JCHR-2304-1718 (R1) Visit : 85 PDF XML

Article Type: Original Research

Multi-Target Hybrid Drugs: A Promising Approach for Treating Alzheimer's, Neurological Diseases, Diabetes, and Cancer

Armineh Rezagholi Lalani 1 (Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran) Fariba Ebrahimbabaie 2 (Family Research Institute, Shahid Beheshti University, Tehran, Iran) Mohsen Sojoudi 3 (Department Operations Research (OR), Management Sciences at Ferdowsi University of Mashhad, Mashhad, Iran) Nima Pouyani 4 (Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran) Marzie Salari Sharifabad 5 (Department of Pharmacy, International Campus, School of Pharmacy, Tehran University of Medical Science, Tehran, Iran) Fatemeh Fakhari 6 (Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran) Sepideh Rezaei 7 (Department of Chemistry, University of Houston, 3585 Cullen Blvd., Fleming Bldg. Rm 112, Houston, TX 77204-5003, USA)

Submited date : 2023-04-03 accepted date : 2023-06-21

Keywords: Acridine, Tacrine, Multi-factorial diseases, Multi-target drugs,

Abstract :

Multi-target drugs are a class of hybrid compounds that can act on multiple targets and diseases simultaneously. These drugs have the potential to treat a range of disorders including Alzheimer's disease, diabetes, and cancer. This review aims to assess the efficacy of acridine- and tacrine-based multi-target hybrid drugs for the treatment of various diseases. In December 2022, a systematic literature search was conducted using "acridine," "tacrine," "multi-target agent, "and "multi-factorial diseases" along with their synonyms. According to the findings, acridine-based conjugates exhibited anti-cancer and anti-diabetic properties by directly inhibiting α-Glucosidase and α-Amylase, and by binding to DNA, topoisomerases, histone deacetylase, and poly (ADP-ribose) polymerase. The results suggest that acridine- and tacrine-based hybrid complexes have the potential to serve as promising multi-target agents for the treatment of Alzheimer's disease, neurological disorders, diabetes, and cancer. Overall, these compounds offer a new approach to drug development by targeting multiple disease pathways with a single agent. In conclusion, the use of multi-target drugs could potentially lead to improved therapeutic outcomes with fewer side effects, making them a promising area of research for the treatment of complex diseases. Keywords for this review include acridine, tacrine, multi-factorial diseases, and multi-target drugs.

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