A convenient method for 14C-labeling of N-(7-chloro-1- methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[ e][1,4]diazepin-3-yl)thiophene-2-carboxamide as CCK-A antagonist

Subject Areas : Journal of the Iranian Chemical Research

Nader Saemian ¹ , Gholamhossein Shirvani ² , Mohsen Javaheri ³

1 - Nuclear science Research School, Nuclear Science & Technology Research Institute
2 - Nuclear science Research School, Nuclear Science & Technology Research Institute
3 - Nuclear science Research School, Nuclear Science & Technology Research Institute

Received: 2011-08-01 Accepted : 2012-03-11 Published : 2012-06-20

Keywords:

References:

[1] B.R. Henke, C.J. Aquino, L.S Birkemo, D.K. Croom, R.W. Dougherty, G.N. Jr. Ervin, M.K. Grizzle,
G.C. Hirst, M.K. James, M.F. Johnson, K.L. Queen, R.G. Sherrill, E.E. Sugg, E.M. Suh, J.W. Szewczyk,
R.J. Unwalla, J. Yingling, T.M. Willson. J. Med. Chem. 40 (1997) 2706 -2725.
[2] R.G. Sherrill, E.E. Sugg, J.Org.Chem. 60 (1995) 730-734.
[3] M.G. Bock, R.M. DiPardo, B.E. Evans, K.E. Rittle, W.L. Whitter, V.M. Garsky, K.F. Gilbert, J.L.
Leighton, K.L. Carson, E.C. Mellin, D.F. Veber, R.S.L. Chang, V.J. Lotti, S.B. Freedman, A.J. Smith, S.
Patel, P.S. Anderson, R.M. Freidinger, J. Med. Chem. 36 (1993) 4276-4292.
[4] R.G.L. Pullen, O.J. Hodgson, J. Pharm. Pharmacol. 39 (1987) 863-864.
[5] B.E. Evans, K.E. Rittle, M.G. Bock, R.M. Dipardo, R.M. Freidinger, W.L. Whitter, G.F. Lundell, D.F.
Veber, P.S. Anderson, R.S.L. Chang, V.J. Lotti, D.J. Cerino, T.B. Chen, P.J. Kling, K.A. Kunkel, J.P.
Springer, J. Hirshfield, J. Med. Chem. 31 (1988) 2235-2246.
[6] A. Khalaj, M. Pirali, H. Matloubi, R. Dowlatabadi, Monatsh. Chem. 132 (2001) 747-752.
N. Saemian et al., J. Iranian Chem. Res. 5 (2) (2012) 103-107
107
[7] T. Kirefu, S.W. Landvatter, A.J. Latter, K.W.M. Lawrie, D.J. Morecombe, K. Willcocks, J. Label.
Compd. Radiopharm 44 (2001) 329-335.
[8] O.K. Arjomandi, N. Saemian, G.Shirvani, M. Javaheri, K. Esmailli, J. Label. Compd. Radiopharm.54
(2011) 363-366.
[9] C.W. Perry, W. Burger, C.M. Dlaney, J. Label. Compd. Radiopharm. 16 (1978) 645-649.
[10] N. Saemian, O.K. Arjomandi, G.Shirvani, J. Label. Compd. Radiopharm.52 (2009) 453-456.
[11] S.C. Schou, J. Label. Compd. Radiopharm. 52 (2009) 173-176.
[12] D.M. Tschaen, R. Desmond, A.O. King, M.C. Fortin, B. Pipik, T.R. Verhoeven, Synth. Commun. 24
(1994) 887-890.
[13] N. Saemian, G. Shirvani, M. Javaheri, J. Radioanal.Nucl. Chem. 281 (2009) 421-423.
[14] A.R. Katritzky, L. Urogdi, A. Mayence, J. Chem. Soc. Chem. Commun. 5 (1989) 337-339.
[15] N. Saemian, G. Shirvani, H. Matloubi, J.Label. Compd.Radiophar m. 49 (2006) 71-76.
[16] H. Matloubi, A. Khalaj, R. Dowlatabadi, G. Shirvani, J. Label. Compd. Radiopharm. 45 (2002) 347-
352.