Anticancer activity of vanadium complexes with bipyridine and phenanthroline

Subject Areas :

طاهره  نشاطی افخم ¹ (دانشجوی کارشناسی ارشد، دانشکده شیمی، واحد تهران شمال، دانشگاه آزاد اسلامی، تهران، ایران)
مرضیه  زارعی دهنوی ² (دانشجوی دکترا، دانشکده شیمی، واحد تهران شمال، دانشگاه آزاد اسلامی، تهران، ایران)
آنیتا  عابدی ³ (دانشیار دانشکده شیمی، واحد تهران شمال، دانشگاه آزاد اسلامی، تهران، ایران)

Received: 2018-03-06 Accepted : 2018-07-06 Published : 2018-08-23

Keywords: Cytotoxicity, Phenanthroline, Vanadium complex, Bipyridine,

Abstract :

Vanadium is a nonessential mineral of the daily diet that has shown beneficial health effects. In the present research, we synthesized and characterized three vanadium complexes,]VOCl)bpy(2]Cl )1(, ]VOCl)phen(2]Cl )2(, and ]VO)SO4()phen(2] )3(, from the reaction of VCl3 and VOSO4 salts with 2,2'-bipyridine)bpy( and 1,10-phenanthroline )phen( ligands. The mentioned complexes were characterized by FT-IR, Mass and UV-Vis spectroscopy. In absorption spectrum of the synthesized compounds, there is a broad weak peak, above 700 nm which is referred to d-d transition of vanadium )IV( center. Moreover, stretching vibration of V=O is appeared around 973-978 cm-1, in IR spectrum. These results confirm the structure of the compounds. Cytotoxic properties of the complexes were checked out on a normal cell NIH3T3 (Rat embryo fibroblast cell) and against three cancer cell lines including HT29 (colon carcinoma), CacoII )colorectal adenocarcinoma(, and T47D )breast cancer cell( by MTT assay and compared with cis-platin. The results indicate compound )1( with low toxicity on normal cells and high cytotoxicity on the cancerous cell lines, is capable of selectively killing properties

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