Preparation, characterization, and investigation of antibacterial activity of ‎polyacrylonitrile/silver metal-organic framework/chitosan nanoparticles/N-acetylcystine ‎multi-component fibrous composites

Subject Areas :

Zeinab Ansari-Asl ¹ , Hadis Rashidi-Kia ² , Esmaeil Darabpour ³

1 - Department of Chemistry, College of Scences, Shahid Chamran University of Ahvaz, Ahvaz, Iran
2 - Department of Chemistry, College of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran
3 - Department of Chemistry, College of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran

Received: 2024-01-27 Accepted : 2024-08-31 Published : 2024-08-30

Keywords: ‎: Metal-organic framework, Chitosan, N-acetylcysteine, Polyacrylonitrile, Composite, Antibacterial activity ‎ ‎,

Abstract :

In this research, fibrous composites with antibacterial activities including polyacrylonitrile (PAN), chitosan nanoparticles (CSNPs), silver metal-organic framework, and N-acetylcysteine ​​(NAC) were prepared by electrospinning method. The prepared fibers were studied using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and elemental mapping using energy-dispersive X-ray spectroscopy (EDS). The obtained results of the antibacterial studies against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) showed that the addition of silver metal-organic framework as well as the antibacterial compounds such as CSNPs and NAC led to the improvement of the antibacterial properties of the fibers. Therefore, these compounds have the potential to be used in medical fields such as wound healing

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