Synthesis and characterization of silver (I) complex containing 4′-(4-quinoline)-2,2′:6′,2′′-terpyridine: Thermal behavior, luminescence study, and cytotoxic properties

Subject Areas :

Badri Zaman Momeni ¹ (Associate Prof. of Inorganic Chemistry, Department of Inorganic Chemistry, Faculty of Chemistry, K.N. Toosi University of Technology, Tehran, Iran.)
Sanaz Kazemzade Anari ² (PhD Student of Inorganic Chemistry, Department of Inorganic Chemistry, Faculty of Chemistry, K.N. Toosi University of Technology, Tehran, Iran.)
Zahra Shahsavari ³ (Assistant Prof. of Biochemistry, Department of Clinical Biochemistry, Faculty of Medicine Shahid Beheshti University of Medical Sciences, Tehran, Iran.)

Received: 2023-01-30 Accepted : 2023-04-03 Published : 2023-05-22

Keywords: Cytotoxicity, Thermal properties, Luminescence, Silver complex, Terpyridine,

Abstract :

The reaction of AgNO3 with 4′-(4-quinoline)-2,2′:6′,2′′-terpyridine (qtpy) has been resulted in the formation of new silver (I) complex [Ag(qtpy)(NO3)] (1). The product has been characterized by elemental analysis, infrared Fourier transmission spectroscopy (FTIR), and nuclear magnetic resonance spectroscopy (1H and 13C NMR). The emission spectrum of complex 1 reveals the presence of π→π* transition with a red shift relative to the free ligand due to the coordination of the ligand to silver center. The thermal properties of 1 indicate that the thermal decomposition process occurs in three steps whereas it is stable up to 320 °C. In addition, the cytotoxic effects of 1 against U87-MG human glioblastoma, MCF-7 human breast cancer, SCOV-3 human ovarian cancer cell line, HT-29 human colorectal cancer, and AGO1522 human normal skin fibroblast cell line were carried out using the MTT assay. The anti-cancer activity of 1 against U87-MG human glioblastoma cell line with IC50 of 6.93 μM is more than that of paclitaxel with IC50 of 27.38 μM.

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