Construction of electrochemical nanosensor based on modified glassy carbon electrode with holmium oxide and carbon nanotubes for determination of efavirenz as a HIV drug

Subject Areas :

Mohammad Mehdi Foroughi ¹

1 - Assistant Professor of Analytical Chemistry, Islamic Azad University, Kerman Branch, Iran.

Received: 2021-05-25 Accepted : 2021-08-29 Published : 2022-08-23

Keywords: Carbon nanotubes, Voltammetry, Efavirenz, Ho2O3 nanoparticles,

Abstract :

Since monitoring of drug metabolism and drug quality control plays an important role in human health, development of easy, correct, and sensitive methods for the detection of active ingredients is important. In the present study, Ho2O3 nanoparticles were synthesized by thermal decomposition method. The morphology and purity of synthesized nanoflowers are characterized through X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy dispersive X-ray spectrometer (EDX). Then, holmium oxide nanoparticles and carbon nanotubes nanocomposite used as a modifier for preparation of modified electrode. Electro-oxidation of efavirenz at the modified electrode was studied using cyclic voltammetry, chronoamperometry, differential pulse voltammetry, and electrochemical impedance spectroscopy. Under optimized conditions, the peak current of differential pulse voltammetry was increased with increasing concentration of efavirenz in the range 0.01 to 500.0 μM. The detection limit of efavirenz was obtained 4.7 nM. In addition, a modified electrode was used to determination of efavirenz in real samples.

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