Invention of a new method for indirect measurement of dimercaprol using the on/off fluorescence emission of functionalized graphene dots

Subject Areas :

Mohammad Hassan Amini ¹ (Chemistry & Chemical Engineering Research Center of Iran,Research Institute of Clean Technologies, Tehran, Iran)

Received: 2021-02-13 Accepted : 2021-04-04 Published : 2022-02-20

Keywords: Measurement, Fluorescence emission, Graphene quantum dots, Dimercaprol,

Abstract :

Dimercaprol with a molecular structure containing two groups of thiols is a suitable drug in the treatment of heavy metal poisoning. The use of graphene quantum dots has been highly regarded by researchers in various fields, including the manufacture of chemical sensors, due to their low cost and availability of raw materials, non-toxicity and simple method of their synthesis. In this study, the fluorescence emission of graphene quantum dots whose surface was functionalized with monoethanolamine was used to develop a new method for indirect measurement of dimercaprol concentration. At first, the fluorescence emission of quantum dots quenched in the presence of mercury ions due to the complex formation of mercury ion with functional groups of quantum dots. Then by increasing dimercaprol and forming a strong complex with mercury, the quantum dots released and their fluorescence emission restored. In the invented method, by detecting the linear relationship between quantum dot emission recovery and dimercaprol concentration, in optimal conditions, dimercaprol was measured at concentrations between 0.1-5 μM and with a detection limit of 50 nM in aqueous solutions.

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