Ultra trace determination of Ranitidine in drinking water, tablet, serum (blood) , and human urine by a colorimetric method based on the aggregation of gold nanoparticles

Subject Areas :

maryam moradi ¹ , mahmoodreza sohrabi ² , saeed mortazavi nik ³

1 - دانشجوی دکتری شیمی تجزیه، دانشکده شیمی، دانشگاه آزاد اسلامی واحد تهران شمال، تهران، ایران
2 - استاد شیمی تجزیه، دانشکده شیمی، دانشگاه آزاد اسلامی واحد تهران شمال، تهران، ایران
3 - استادیار شیمی معدنی، دانشکده شیمی، دانشگاه آزاد اسلامی واحد تهران شمال، تهران، ایران

Received: 2019-12-25 Accepted : 2020-07-15 Published : 2021-05-22

Keywords: Spectrophotometry, Gold nanoparticles, colorimetric, Ranitidine, Surface plasmon resonance, Ultra-trace,

Abstract :

Abstract: This research introduces a simple, sensitive, and rapid ultraviolet- visible spectrophotometry method for determination of ultra-trace amount of Ranitidine (RAN) in several sample such as drinking water, tablet, serum (blood), and human urine using gold nanoparticles (AuNPs). The surface plasmon resonance (SPR) property of AuNPs and the interaction between RAN and AuNPs is the base of this method. The addition of RAN into AuNPs led to the aggregation of AuNPs. Transmission electron microscopy (TEM) proved aggregation of AuNPs in the presence of RAN. Also, the size of the nanoparticles distribution was evaluated by dynamic light scattering (DLS). The parameters that affect the absorbance such as pH, type and volume of buffer, AuNPs concentration, interaction time, ionic strength, and interfering ions were investigated and optimized. Linear range was obtained 25-300 μgL-1 in the optimum conditions. Also, the correlation coefficient (R2 =0.9955) and the limit of detection (LOD), and limit of quantification (LOQ) were equal to 1.45 μgL-1, and 1.63 μgL-1, respectively. In addition, the effect of interfering species was investigated. Eventually, the results showed that the proposed method had a high potential for rapid, sensitive, and accurate determination of RAN

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