Variations of Thyroid Peroxidase Levels in Patients with Hyperprolactinemia Caused by Pitutary Adenoma

Subject Areas : Developmental biology of plants and animals , development and differentiation in microorganisms

Siyamak  Nayebi ¹ (, Department of Biochemistry,Payam Noor University, Tehran, Iran)
Reza  Hajihosseini ² (Department of Biochemistry, Payam Noor University, Tehran, Iran)

Received: 2023-01-02 Accepted : 2023-03-10 Published : 2024-02-12

Keywords: bromocriptine, pitutary, thyroid peroxidase,

Abstract :

Bromocriptine is used as an effective drug for patients with hyperplrolactinemia. Thyroid peroxidase (TPO) is an enzyme of thyrocytes membrane. The enzyme has a gret role in formation of T4 and T3 by oxidizing tyrosine residues in thyroglobulines. In this study, samples were collected from two groups of women with hyperprolactinemia over a period of 10 months. The first group includes 25 normal clients and individuals which is known as euthyroid (with normal thyroid function and normal levels of thyroid gland hormones) in the age range of 30-37 years (samples 1 to 25) and the second group includes 25 other persons with the same condition in the age range of 38-45 years (samples 26 to 50). Both groups used only bromocriptine tablets as drug treatment with the dose of 5mg/day in a period of at least 6 months. The levels of anti TPO antibodies which is directly proportional to levels of the enzyme, measured both before and after the treatment with bromocriptine. In most cases bromocriptine treatment caused a decrease in levels of TPO enzyme antibodies. In current study, effectivenes of bromocriptine on TPO levels was confirmed by statistical assays.