Effect of propolis Alcoholic Extract on Oogenesis In NMRI mice in vivo
Subject Areas : Developmental biology of plants and animals , development and differentiation in microorganismssamaneh tohidi 1 , kazem parivar 2
1 - Islamic Azad University Science And Reserch Branch
2 - Islamic Azad University Scince And Reserch Branch
Keywords: Ovary, Uterus, Oogenesis, Alcoholic extract of propolis,
Abstract :
Introduction:antioxidants prevent the occurrence of unwanted factors in the female reproductive system by absorbing free radicals in damaged cells which may cause damage to the cell's enzymes and DNA changes and infertility.Propolis is a resinous substance collected by honeybees from some plant sources to disinfect the hive's environment.The propolis is rich in antioxidants. Given that the infertility rate due to the production of oxidative esters has increased dramatically in recent decades, and on the other hand, propolis acts as an antioxidant. Method:There are five mouse groups in this study:Control group (Without receiving alcoholic extract of propolis), Sham group (receiving 1 cc distilled water for 30 days), experimental groups 1, 2 and 3 (Under the influence of concentrations of 0.75, 0.57 and 0.18 mg / ml of alcoholic extract of propolis, 1 cc for 30 days). All mice were autopsied after gavage completion and their uterus and ovaries were isolated and for final examinations were prepared for microscopic study after taking the necessary steps. Results: Propolis being a strong antioxidant, increased the number of all follicles except the atritic follicles and hence uterine layers of the endometrium and primetriumwere increased and the myometrial layer decreased. Conclusion:Gavage of propolis alcoholic significantly is effective on ovary follicls and uterus tissue Keywords: Alcoholic extract of propolis, Oogenesis, Uterus, Ovary
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