Abstract :
Deltamethrin insecticide widely used pesticides with harmful effects on the ecosystem and liver organ involved in the metabolism of toxic substances. According to antioxidant role of vitamin C, the effects of exposure to deltamethrin on rat's liver were studied. For this purpose, 63 rats (Wistar) weighing 200 ± 15 g were selected and divided into 9 groups. After determination of lethal dose for deltamethrin (20mg / kg/b.wt), (5/2, 5 and 10) mg/ kg/b.wt of this was chosen for this experiment. Groups were selected in the control (no treatment), group 1 (distilled water), group 2 were injected ( 20 mg / kg/b.wt) Vitamin C, 3 treatment groups, respectively (5/2, 5 and 10) mg / kg / b.wt of deltamethrin and 3 groups treated with the same doses of deltamethrin + vitamin C (20mg / kg/b.wt) within 14 days, injected intraperitoneal. At the end of the treatment period, Rat's livers were separated, prepared and placed in tissue processor. Prepared serial sections (5 μ), were stained and studied with L.M (40 x) and determined the degree of damage. Using ratings method, damage of tissue were determinate in 0 to 4 degrees that indicate the minimum to maximum damage. Obtain data analyzed by using SPSS (17) and ANOVA and groups were compared in significance level (P< 0.05) with LSD and Tukey's test. According to the results, changes in nucleuses lining to the cell necrosis were seen in the groups which exposed to deltamethrin. These damages were recompensed partially in groups which treated with vitamin C especially in group with low dose of toxin.
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