The effect of sulindac on permethrin-induced seizures in mice

Subject Areas : Smal Animal Medicine

mohammad amin torabi ¹ , ََArian Jam ² , Melina Daghighian ³

1 - Doctor of Veterinary Medicine Student, Faculty of Veterinary Medicine, Islamic Azad University, Research Sciences Branch, Tehran, Iran
2 - Doctor of Veterinary Medicine Student, Faculty of Veterinary Medicine, Islamic Azad University, Karaj Branch, Karaj, Iran
3 - Doctor of Veterinary Medicine Student, Faculty of Veterinary Medicine, Islamic Azad University, Shushtar Branch, Shushtar, Iran.

Received: 2022-03-11 Accepted : 2025-04-24 Published : 2025-04-28

Keywords: permethrin, sulindac, seizure, anti-inflammatory,

Abstract :

Permethrin is a synthetic pyrethroid toxin with insecticidal properties. It is used in agriculture as an insecticide and in animals and humans to kill foreign parasites. Sulindac is a non-steroidal anti-inflammatory drug widely used to treat pain and inflammation. This experimental study was performed to evaluate the effect of Solindac on permethrin-induced seizures in 90 male NMRI mice weighing 25 g at doses of Sulindac at concentrations of (1, 5, 10, 15, 20, 25 and 30 mg). Received intraperitoneally and 45 minutes before intraperitoneal injection at a concentration (200 mg / kg). After injection of permethrin, clonic and tonic seizures were evaluated. The results showed that sulindac was dose-dependent. Reduces the severity of seizures caused by permethrin, so that at doses of 15 and 30 mg / kg had the lowest (P <0.05) and maximum (P <0.001) anticonvulsant effects, respectively. The seizures induced by permethrin are effective, possibly due to the inhibitory effect on the central nervous system cyclooxygenase enzyme.