ساختار، نحوه عمل و بیان GnRH و گیرنده GnRH در اندام‪های تناسلی محیطی و تنظیم آنها توسط استرادیول-17β

Subject Areas : Camel

اچ.ب. سیفتسی ¹

1 - Department of Animal Science, School of Agriculture, Selçuk University, Konya 42075, Turkey

Received: 2014-12-11 Accepted : 2015-03-15 Published : 2015-12-01

Keywords: GnRH, تخمدان, استرادیول, مجرای تخم بر, رحم,

Abstract :

مطالعات نشان داده‪اند که استرادیول-17β (E2) هورمون آزاد کننده گنادوتروپین (GnRH) و بیان گیرنده GnRH در هیپوتالاموس و هیپوفیز را تنظیم می‪کند. مطالعات متعدد نشان داده‪اند که GnRH و گیرنده آن در اندام‪های تناسلی محیطی نیز بیان می‪شوند و اطلاعات کمی در مورد آن شناخته شده است. در این مطالعه، به ساختار، وظیفه، بیان محیطی GnRH و گیرنده GnRH و تنظیمات آن با E2 بررسی شد. مطالعات  in vivoو in vitro نشان داد که E2 سبب کاهش بیان ژن GnRH و تنظیم بیان گیرنده GnRH به صورت وابسته به زمان می‪شود. با این وجود، مکانیسم دقیقی تاکنون به وضوح توضیح داده نشده است.

References:

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